Placenta-directed gene therapy for fetal growth restriction

Seminars in Fetal & Neonatal Medicine
Tara Krishnan, Anna L David

Abstract

Fetal growth restriction (FGR) is a serious pregnancy complication affecting ∼8% of all pregnancies. There is no treatment to increase fetal growth in the uterus. Gene therapy presents a promising treatment strategy for FGR, with the use of adenoviral vectors encoding for proteins such as vascular endothelial growth factor (VEGF) and insulin-like growth factor demonstrating improvements in fetal growth, placental function, and neonatal outcome in preclinical studies. Safety assessments suggest no adverse risk to the mother or fetus for VEGF maternal gene therapy; a clinical trial is in development. This review assesses research into placenta-directed gene therapy for FGR, investigating the use of transgenes and vectors, their route of administration in obstetrics, and the steps that will be needed to take this treatment modality into the clinic.

Citations

Jan 22, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Young Ran KimHee Young Cho
Dec 31, 2020·Human Reproduction Update·Arthur ColsonAmanda N Sferruzzi-Perri
Nov 17, 2021·Neural Regeneration Research·Kamilla Faritovna IdrisovaRuslan Faridovich Masgutov

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