Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models.

Cancer Research
Lei XuDai Fukumura

Abstract

The role of placenta growth factor (PlGF) in pathologic angiogenesis is controversial. The effects of PlGF on growth, angiogenesis, and metastasis from orthotopic tumors are not known. To this end, we stably transfected three human cancer cell lines (A549 lung, HCT116 colon, and U87-MG glioblastoma) with human plgf-2 full-length cDNA. Overexpression of PlGF did not affect tumor cell proliferation or migration in vitro. The growth of PlGF-overexpressing tumors grown orthotopically or ectopically was impaired in all three tumor models. This decrease in tumor growth correlated with a decrease in tumor angiogenesis. The PlGF-overexpressing tumors had decreased vessel density and increased vessel diameter, but vessel permeability was not different from the parental tumors. Tumors overexpressing PlGF exhibited higher levels of PlGF homodimers and PlGF/vascular endothelial growth factor (VEGF) heterodimers but decreased levels of VEGF homodimers. Our study shows that PlGF overexpression decreases VEGF homodimer formation and inhibits tumor progression.

References

May 11, 2002·Nature Reviews. Cancer·Rakesh K JainDai Fukumura
Aug 2, 2002·Biochemical and Biophysical Research Communications·Aernout LuttunLieve Moons
Jun 12, 2004·Circulation Research·Meit BjörndahlYihai Cao
Aug 30, 2005·The American Journal of Pathology·Claire Lewis, Craig Murdoch

❮ Previous
Next ❯

Citations

Dec 3, 2008·Cell Biochemistry and Biophysics·Payaningal R SomanathTatiana V Byzova
Nov 26, 2008·Nature Reviews. Cancer·Christian FischerPeter Carmeliet
Jun 25, 2010·Nature Reviews. Cancer·Alicia S ChungNapoleone Ferrara
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Eva-Maria HedlundYihai Cao
Dec 26, 2012·Proceedings of the National Academy of Sciences of the United States of America·Eva-Maria Eleonora HedlundYihai Cao
Oct 15, 2008·The Journal of Experimental Medicine·Kiichiro YanoWilliam C Aird
Feb 1, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shan LiaoLei Xu
Apr 5, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jieqiong LiuLei Xu
Aug 25, 2009·Diagnostic Pathology·Sebastian MarwitzTorsten Goldmann
Sep 6, 2013·International Journal of Molecular Sciences·Karin ZinsDietmar Abraham
Jan 6, 2012·Experimental & Molecular Medicine·Ki Jo KimWan Uk Kim
Oct 10, 2014·Expert Opinion on Therapeutic Targets·Mieke Dewerchin, Peter Carmeliet
Apr 18, 2012·Expert Opinion on Biological Therapy·Dorte Lisbet Nielsen, Lisa Sengeløv
Nov 11, 2015·Proceedings of the National Academy of Sciences of the United States of America·Xing GaoLei Xu
May 14, 2011·Molecular Aspects of Medicine·Sònia TuguesLena Claesson-Welsh
Mar 25, 2011·Cancer Letters·Domenico Ribatti
Apr 15, 2011·Journal of Pregnancy·Mitsuko FuruyaIchiro Aoki
May 21, 2015·Proceedings of the National Academy of Sciences of the United States of America·Xiaojuan YangYihai Cao
May 20, 2014·Biochimica Et Biophysica Acta·Rajesh N Gacche, Rohan J Meshram
Aug 7, 2013·Proceedings of the National Academy of Sciences of the United States of America·Xiaojuan YangYihai Cao
Aug 8, 2009·The Journal of Thoracic and Cardiovascular Surgery·Fernando Villegas-AlvarezEduardo E Montalvo-Jave
Nov 9, 2017·Journal of Human Hypertension·K ChauA Makris
Nov 4, 2017·Journal of Molecular Endocrinology·Yingchun LiEmily J Su
Apr 5, 2008·International Journal of Cancer. Journal International Du Cancer·Maija P ValtaPirkko Härkönen
Mar 4, 2020·The Journal of Clinical Investigation·Teresa GaglianoGeorgios Giamas
Jun 10, 2009·International Journal of Immunopathology and Pharmacology·L AlboniciV Manzari
Jun 21, 2019·International Journal of Molecular Sciences·Loredana AlboniciRoberto Bei
Sep 17, 2008·Cancer Research·Mark KerberMarcia Regina Machein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.