Placental abruption and subsequent risk of pre-eclampsia: a population-based case-control study

Paediatric and Perinatal Epidemiology
Samantha E ParkerCande V Ananth

Abstract

Pre-eclampsia and placental abruption may share a common pathophysiologic mechanism, namely, uteroplacental ischaemia. The aim of this study was to investigate the association between placental abruption and risk of pre-eclampsia in a subsequent pregnancy, and to determine whether the association differs by the gestational age at the time of abruption. A nested case-control study among multiparous women in the Medical Birth Register of Finland from 1996-2010 was conducted. Cases of pre-eclampsia (n = 6487) and frequency matched controls (n = 25,948) were linked to the Hospital Discharge Registry to ascertain data on prior abruption. Abruption was categorised as preterm (<37 weeks) or term (≥37 weeks) based on the gestational age at delivery. We fit logistic regression models to evaluate the associations between abruption and the odds of pre-eclampsia in the subsequent pregnancy before and after adjusting for potential confounders. Preterm abruption was associated with over a twofold increase in risk of pre-eclampsia [odds ratio (OR) 2.2, 95% confidence interval (CI) 1.5, 3.3] in a subsequent pregnancy. In contrast, term abruption was not associated with pre-eclampsia (OR 1.1, 95% CI 0.7, 1.7). The association between preterm ab...Continue Reading

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Citations

Sep 24, 2015·American Journal of Obstetrics and Gynecology·Cande V AnanthJason D Wright
Apr 15, 2016·The Journal of Obstetrics and Gynaecology Research·Liangcheng WangHiroyuki Seki
Oct 16, 2018·The Journal of Clinical Endocrinology and Metabolism·Xian-Hua LinHe-Feng Huang
Feb 28, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rebecca L RohdeJen Jen Chang
Aug 20, 2019·Neurology·Cande V AnanthAnne-Marie Nybo Andersen
May 1, 2020·BMJ : British Medical Journal·Liv G KvalvikQuaker E Harmon
Jan 18, 2020·Case Reports in Obstetrics and Gynecology·Lily CriscioneKimberly Hickey

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