Placental and fetal growth restriction, size at birth and neonatal growth alter cognitive function and behaviour in sheep in an age- and sex-specific manner

Physiology & Behavior
Damien S HunterKathryn L Gatford

Abstract

Intrauterine growth restriction and slow neonatal growth in humans are each associated with poorer learning, memory and cognitive flexibility in childhood and adulthood. The relative contributions of pre- and post-natal growth to cognitive outcomes are unclear, however. We therefore compared performance in learning, memory and reversal tasks using a modified Y-maze at 18 and 40 weeks of age in offspring of placentally-restricted (PR: 10 M, 13 F) and control (23 M, 17 F) ovine pregnancies. We also investigated relationships between size at birth, neonatal growth rates and cognitive outcomes. PR had limited effects on cognitive outcomes, with PR males requiring more trials to solve the initial learning task than controls (P=0.037) but faster completion of reversal tasks in both sexes at 18 weeks of age. In males, neonatal growth rate correlated inversely with numbers of trials and total time required to solve memory tasks at 40 weeks of age. In females, bleat frequency in the first reversal task at 18 weeks of age correlated positively with birth weight (r=0.734, P<0.05) and neonatal growth rate (r=0.563, P<0.05). We conclude that PR induces limited effects on cognitive outcomes in sheep, with some evidence of impaired learning i...Continue Reading

References

Jul 1, 1987·Acta paediatrica Scandinavica·A TenovuoR Erkkola
Jan 1, 1985·Acta Paediatrica Scandinavica. Supplement·I Brandt
Oct 1, 1973·Archives of Disease in Childhood·J Dobbing, J Sands
Apr 1, 1994·Acta Paediatrica. Supplement·K Albertsson-Wikland, J Karlberg
Aug 30, 1995·Early Human Development·P B ToftO Henriksen
Sep 1, 1996·Biological Psychiatry·N BreslauG Brown
Dec 24, 1997·Acta Paediatrica. Supplement·K Albertsson-Wikland, J Karlberg
Jan 18, 2002·The New England Journal of Medicine·Maureen HackNancy Klein
Apr 3, 2002·The Journal of Endocrinology·K L GatfordJ A Owens
Apr 16, 2004·Behavioural Brain Research·Hans W ErhardStewart M Rhind
Jan 14, 2005·Developmental Science·Kimberly G NobleMartha J Farah
Sep 6, 2005·Brain Research Bulletin·Y LeitnerC G Pick
Feb 9, 2006·The Journal of Clinical Endocrinology and Metabolism·Alexander JonesDavid I W Phillips
Apr 22, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Miles J De BlasioJulie A Owens
Jun 6, 2006·Early Human Development·Kari Anne Indredavik EvensenTorstein Vik
Mar 1, 2007·American Journal of Physiology. Endocrinology and Metabolism·J A OwensK L Gatford
May 25, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E TidemanD Ley
Jun 26, 2007·Physiology & Behavior·Lucile GreiveldingerAlain Boissy
Aug 3, 2007·Behavioural Brain Research·Elisabetta VersaceGiorgio Vallortigara
Jan 6, 2009·Journal of Child Psychology and Psychiatry, and Allied Disciplines·R GevaS Harel
Jul 1, 2009·Pediatrics·Julia B PitcherVivienne M Moore
Aug 12, 2009·Best Practice & Research. Clinical Obstetrics & Gynaecology·Srividhya Sankaran, Phillipa M Kyle
Feb 10, 2011·PloS One·A Jennifer Morton, Laura Avanzo
Jan 4, 2012·Developmental Psychobiology·Timothy B JohnsonTimothy A Cudd
Mar 20, 2012·PloS One·Rosângela F L BatistaHeloisa Bettiol
Oct 26, 2012·Journal of Animal Science·D S van der LindenS A McCoard
Mar 5, 2013·The Journal of Pediatrics·Gro C C LøhaugenMarit Martinussen

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Citations

Jun 12, 2016·Physiology & Behavior·Damien S HunterKathryn L Gatford
Oct 1, 2016·Journal of Developmental Origins of Health and Disease·H DickinsonJ L Morrison
Oct 17, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Janna L MorrisonRoss L Tellam
Jun 18, 2021·Veterinary Research Communications·F L HenriqueC G Titto

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