Placental and milk transmission of trichothecene mycotoxins, nivalenol and fusarenon-X, in mice

Toxicon : Official Journal of the International Society on Toxinology
Amnart PoapolathepSusumu Kumagai

Abstract

In order to investigate the transfer of nivalenol (NIV) and fusarenon-X (FX) from pregnant to fetal mice and from lactating to suckling mice, (3)H-NIV or (3)H-FX was given p.o. to pregnant or lactating mice. Radioactivity was detected in the whole fetal tissues as well as the fetal liver and kidney, the levels being comparable to those of the maternal tissues. Radioactivity was also detected in the milk, and liver and kidney tissues taken from suckling mice of both (3)H-NIV or (3)H-FX administered dams. HPLC analysis of fetal tissue homogenates from non-labeled FX- or NIV-administered pregnant mice revealed transmission of NIV to fetuses after administration of either toxin. In mice given the non-labeled FX, major and minor peaks of NIV and FX on HPLC were noted in suckling pup tissue homogenates. The results demonstrate that NIV transfers in unchanged form to fetal or suckling mice via placenta or milk, respectively, and that FX does so mainly after being metabolized to NIV in maternal body.

References

Aug 1, 1987·Journal of Applied Toxicology : JAT·C G Rousseaux, H B Schiefer
Oct 1, 1984·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·D B PreluskyP M Scott

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Citations

Apr 3, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S DänickeU Tiemann
Oct 11, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S Cavret, S Lecoeur
Sep 29, 2015·Research in Veterinary Science·Sawinee AupanunAmnart Poapolathep
Jul 2, 2014·Toxicology Letters·Samak SutjaritAmnart Poapolathep
Feb 11, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Thanit SaengtienchaiAmnart Poapolathep
Aug 19, 2016·The Journal of Veterinary Medical Science·Sawinee AupanunAmnart Poapolathep
Sep 3, 2018·Toxicon : Official Journal of the International Society on Toxinology·Wanchalerm PhruksawanAmnart Poapolathep

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