Placental anomalies in a viable cloned calf

Cloning
J R HillJ B Cibelli

Abstract

Placental anomalies are associated with a high mortality rate in mammalian cloning programs. In this report, we detail the very unusual occurrence of a grossly abnormal placenta that supported a viable cloned calf to term. The placenta was recovered intact 3 h following birth, and its weight was within normal limits (4.3 kg). The chorioallantois of the cloned transgenic female Holstein calf contained only 26 cotyledons. Twelve of these were enlarged and functional. Six were poorly developed, and eight were degenerating. The 12 functional cotyledons ranged in diameter from 8 to 20 cm. The nongravid horn had six rudimentary (<5 cm in diameter) cotyledons and eight cotyledons that remained as oval, mineralized plaques. Despite the reduction in number of placentomes, there was no adventitial placentation. Although this report documents observations from a single case, it does show that a morphologically deficient placenta was able to support development to term and resulted in a viable calf.

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Citations

Sep 8, 2012·Reproduction, Fertility, and Development·Míryan L V AlbertoMaria A Miglino
Mar 11, 2003·Cloning and Stem Cells·Wafa C Slimane-Bureau, W Allan King
Oct 26, 2002·Cloning and Stem Cells·Kazuyoshi HashizumeYoshiaki Izaike
Jan 5, 2006·Cloning and Stem Cells·Kara A HoffertGary B Anderson
Mar 28, 2007·Cloning and Stem Cells·Cynthia A BatchelderGary B Anderson
Dec 25, 2007·Cloning and Stem Cells·Su-Jin ChoIl-Keun Kong
Dec 25, 2007·Cloning and Stem Cells·Atsushi IdetaKazuhiro Saeki
Apr 18, 2003·Biology of Reproduction·Greg S ArcherJorge A Piedrahita
Dec 19, 2003·Biology of Reproduction·Osman V PatelKazuyoshi Hashizume
Aug 27, 2004·Biology of Reproduction·Daniela O BrandãoHenrik Callesen
Nov 11, 2014·Annual Review of Animal Biosciences·Jonathan R Hill
Jul 30, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Hiroki HirayamaAkira Minamihashi
Jan 25, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·C J FletcherI C McMillen
Jan 3, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Marcelo BertoliniGary B Anderson
Aug 31, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·M BertoliniG B Anderson
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Mar 1, 2005·Molecular Reproduction and Development·Hirofumi HanadaW Allan King
Sep 11, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ben LiuSijiu Yu

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