Placental control of fetal growth

Reproduction, Fertility, and Development
J S RobinsonJ Owens

Abstract

The placenta exerts its effects on the growth of the fetus from the beginning of pregnancy via metabolic and endocrine mechanisms. To achieve this, the placenta exchanges a wide array of nutrients, endocrine signals, cytokines and growth factors with the mother and the fetus. These exchanges modulate or programme fetal growth and development. This review concentrates on the function and structure of the placenta in humans and in animals, and the effects of experimental perturbation of placental size and function on fetal growth. The consequences for fetal growth of varying the abundance of peptides or, by deleting genes, insulin-like growth factors or cytokines, are also described. Maternal nutritional and hormonal state from as early as the first few days after fertilization, can influence the growth rate of the placenta and the fetus and also the length of gestation. Influences on placental development and their consequences will clearly have an impact on the placental control of fetal growth. Variations in the maternal environment and consequent perturbation of the metabolic and endocrine environment of the placenta and fetus are implicated as being responsible for the associations between prenatal growth of the placenta and...Continue Reading

Citations

Apr 25, 2000·Obstetrics and Gynecology·R R Huxley
Sep 23, 2003·Social Science & Medicine·David A Coall, James S Chisholm
Jun 11, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·K M Godfrey
Dec 12, 2001·Molecular and Cellular Endocrinology·M L Langdown, M C Sugden
Apr 1, 1999·Animal Reproduction Science·V E PerryN Phillips
Nov 18, 2000·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·E OberdörsterL K Irwin
Jan 16, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·T Subramoniam
Dec 1, 2002·Nutrition Research Reviews·Alan W Bell, Richard A Ehrhardt
May 8, 1998·The Proceedings of the Nutrition Society·K Godfrey, S Robinson
May 11, 2002·The Proceedings of the Nutrition Society·Jane CoadJane Morgan
Aug 14, 2012·Ecology of Food and Nutrition·Crystal L PatilSera L Young
Aug 25, 2001·American Journal of Respiratory and Critical Care Medicine·V L CliftonP G Gibson
Apr 27, 2010·PloS One·Jonathan H GrabowskiPhilip O Yund
Sep 6, 2001·Hormones and Behavior·E B Keverne
Apr 23, 2009·American Journal of Human Biology : the Official Journal of the Human Biology Council·Suzette D Tardif, Corinna N Ross
Mar 18, 2016·Journal of Developmental Origins of Health and Disease·A J LewisM Galbally
May 24, 2006·Animal Reproduction Science·L P LandimJ M Garcia
Jan 23, 1999·Biology of Reproduction·S A RobertsonR F Seamark
Jul 26, 2018·Journal of Perinatal Medicine·Roberto RomeroOffer Erez
Dec 7, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Susanta K BehuraThomas E Spencer
Jun 1, 1997·British Journal of Obstetrics and Gynaecology·K M GodfreyC Osmond
Oct 3, 2002·Pediatric Research·Mark Hanson
Oct 31, 2001·Public Health Nutrition·K M Godfrey, D J Barker
Aug 23, 2001·Scandinavian Cardiovascular Journal : SCJ·A Holmäng

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