Placental DNA Methylation Related to Both Infant Toenail Mercury and Adverse Neurobehavioral Outcomes

Environmental Health Perspectives
Jennifer Z J MaccaniCarmen J Marsit

Abstract

Prenatal mercury (Hg) exposure is associated with adverse child neurobehavioral outcomes. Because Hg can interfere with placental functioning and cross the placenta to target the fetal brain, prenatal Hg exposure can inhibit fetal growth and development directly and indirectly. We examined potential associations between prenatal Hg exposure assessed through infant toenail Hg, placental DNA methylation changes, and newborn neurobehavioral outcomes. The methylation status of > 485,000 CpG loci was interrogated in 192 placental samples using Illumina's Infinium HumanMethylation450 BeadArray. Hg concentrations were analyzed in toenail clippings from a subset of 41 infants; neurobehavior was assessed using the NICU Network Neurobehavioral Scales (NNNS) in an independent subset of 151 infants. We identified 339 loci with an average methylation difference > 0.125 between any two toenail Hg tertiles. Variation among these loci was subsequently found to be associated with a high-risk neurodevelopmental profile (omnibus p-value = 0.007) characterized by the NNNS. Ten loci had p < 0.01 for the association between methylation and the high-risk NNNS profile. Six of 10 loci reside in the EMID2 gene and were hypomethylated in the 16 high-risk...Continue Reading

References

Sep 1, 1992·Toxicology and Applied Pharmacology·W Y BoadiS Yannai
Jan 1, 1989·Progress in Neurobiology·B H Choi
Dec 11, 1997·Neurotoxicology and Teratology·P GrandjeanP J Jørgensen
Feb 28, 2002·Current Opinion in Neurobiology·Karen S Ho, Matthew P Scott
May 11, 2002·Environmental Health Perspectives·Karolin AskMarie Vahter
Jul 9, 2002·Biochemical and Biophysical Research Communications·Joachim KremerskothenAngelika Barnekow
Jul 30, 2002·The Journal of Biological Chemistry·Keiji SatoKazuhiro Nagata
Feb 14, 2003·Journal of Cell Science·Robert A McCarthy, W Scott Argraves
Jul 9, 2004·Toxicology and Applied Pharmacology·S Allen Counter, Leo H Buchanan
Nov 25, 2004·Schizophrenia Research·Hsiang-Yin ChenChia-Hsiang Chen
Apr 25, 2006·Biostatistics·W Evan JohnsonAriel Rabinovic
Aug 17, 2006·Journal of Exposure Science & Environmental Epidemiology·Judy R ReesMargaret R Karagas
Dec 26, 2006·Neurobiology of Disease·Dervila GlynnA Jennifer Morton
Jan 24, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jennifer S BennettsCarol Wicking
Oct 13, 2007·Environmental Health : a Global Access Science Source·Lars BjörkmanMarie Vahter
Jul 16, 2008·Molecular and Cellular Neurosciences·J LarssonK Forsberg-Nilsson
Apr 18, 2009·Developmental Neuroscience·Barry M Lester, James F Padbury
Jul 21, 2009·American Journal of Reproductive Immunology : AJRI·Matthew A Maccani, Carmen J Marsit
Nov 17, 2009·Environmental Research·Carmen FreireMariana-Fátima Fernández
Dec 9, 2009·Pediatrics·Jing LiuHenrietta Bada
Aug 25, 2010·Journal of the American Academy of Child and Adolescent Psychiatry·Benjamin M NealeUNKNOWN IMAGE II Consortium Group
Oct 1, 2010·Bioinformatics·Pei Fen KuanHaitao Chu
Nov 19, 2010·Immunogenetics·Charisse Flerida A PasajeHyoung Doo Shin
Jan 5, 2011·Neuropharmacology·Nicholas J Bradshaw, David J Porteous
Apr 28, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Amanda C FilibertoCarmen J Marsit
Jul 16, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Carolyn E BanisterCarmen J Marsit
Sep 23, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Melissa SuterKjersti M Aagaard-Tillery
Sep 29, 2011·Human Mutation·Laura A LetticeDavid R FitzPatrick
Oct 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yi HuClemens R Scherzer
Oct 19, 2011·Environmental Health Perspectives·Charlotte S Wilhelm-BenartziCarmen J Marsit
Dec 14, 2011·The Journal of Pediatrics·Carmen J MarsitJia Chen
Jan 31, 2012·American Journal of Epidemiology·Sabrina LlopUNKNOWN INMA Project

❮ Previous
Next ❯

Citations

Jan 30, 2016·Child Development·Barry M LesterCarmen Marsit
Apr 30, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Andres CardenasCarmen J Marsit
Jul 18, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Maya A KappilJia Chen
Oct 3, 2015·American Journal of Obstetrics and Gynecology·Vania JanuarRichard Saffery
Apr 9, 2016·Environment International·Samantha L KingsleyGregory A Wellenius
Jul 1, 2016·BMC Bioinformatics·E Andres HousemanCarmen J Marsit
Aug 22, 2016·Reproductive Toxicology·Todd M EversonCarmen J Marsit
Oct 28, 2016·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Martina RudgalvyteGarry Wong
Sep 8, 2016·Archives of Toxicology·Claudia GundackerMarkus Hengstschläger
Sep 22, 2017·Environmental Health Perspectives·Andres CardenasAndrea A Baccarelli
Mar 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jia ZhongAndrea A Baccarelli
Apr 27, 2019·PloS One·Danielle A Clarkson-TownsendCarmen J Marsit
May 18, 2019·Clinical Epigenetics·Shizhao LiTrygve O Tollefsbol
Jan 31, 2018·Epigenomics·Barry M Lester, Carmen J Marsit
Jan 13, 2018·Annual Review of Public Health·Elizabeth M Martin, Rebecca C Fry
Apr 4, 2020·Journal of Developmental Origins of Health and Disease·Shino Nishizawa-JotakiChisato Mori
Apr 28, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Benjamin B GreenCarmen J Marsit
Nov 14, 2019·Toxics·Megan Culbreth, Michael Aschner
Jul 29, 2018·Current Environmental Health Reports·Todd M Everson, Carmen J Marsit
May 27, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Allison A AppletonCarmen J Marsit
Aug 13, 2020·Developmental Psychobiology·Jerrold S Meyer, Melinda A Novak
Sep 4, 2020·Neurotoxicology·Omamuyovwi M IjomoneMichael Aschner
Apr 3, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Max T AungM Daniele Fallin
Apr 20, 2021·Environmental Epidemiology·Whitney CowellRosalind J Wright

❮ Previous
Next ❯

Methods Mentioned

BETA
SGA
chip
cesarean section
PCR

Software Mentioned

ComBat
R
R Core Team

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.