Placental epigenetic patterning of glucocorticoid response genes is associated with infant neurodevelopment

Epigenomics
Alison G PaquetteCarmen J Marsit

Abstract

To determine associations between methylation of NR3C1, HSD11B2, FKBP5 and ADCYAP1R1 and newborn neurobehavioral outcomes. In 537 newborns, placental methylation was quantified using bisulfite pyrosequencing. Profiles of neurobehavior were derived via the Neonatal Intensive Care Unit Network Neurobehavioral Scales. Using exploratory factor analysis, the relationships between methylation factor scores and neurobehavioral profiles were examined. Increased scores of the factor characterized by NR3C1 methylation were associated with membership in a reactive, poorly regulated profile (odds ratio: 1.47; 95% CI: 1.00-2.18), while increased scores of the factor characterized by HSD11B2 methylation reduced this risk. These results suggest that coordinated regulation of these genes influences neurobehavior and demonstrates the importance of examining these alterations in a harmonized fashion.

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Citations

Jul 2, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Alison G PaquetteCarmen J Marsit
Oct 26, 2016·Development and Psychopathology·Audrey R TyrkaStephanie H Parade
Jun 9, 2017·Human Molecular Genetics·Irina ManokhinaWendy P Robinson
Aug 14, 2018·Journal of Developmental Origins of Health and Disease·J F Felix, C A M Cecil
Jul 5, 2017·Journal of Perinatal Medicine·Maya A DeyssenrothJia Chen
Nov 6, 2018·Infancy : the Official Journal of the International Society on Infant Studies·Wei ZhangYoko Nomura
Jul 28, 2019·Hormone Molecular Biology and Clinical Investigation·Ying-Xue Ding, Hong Cui
Dec 27, 2016·Frontiers in Endocrinology·Chinthika PiyasenaAmanda J Drake
May 27, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Allison A AppletonCarmen J Marsit
Feb 26, 2019·Frontiers in Behavioral Neuroscience·Alonzo T FolgerKatherine Bowers
May 8, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Hudson P SantosRebecca C Fry
Jul 19, 2019·International Journal of Molecular Sciences·Katherine R Knox-ConcepcionLubo Zhang
Jun 3, 2021·International Journal of Environmental Research and Public Health·Aurélie NakamuraJohanna Lepeule

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Methods Mentioned

BETA
nuclear translocation
PCR
SGA

Software Mentioned

Psych
R

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