Placental expression of insulin-like growth factor-I, fibroblast growth factor-basic and neural cell adhesion molecule in pregnancies with small for gestational age fetuses

Journal of Perinatology : Official Journal of the California Perinatal Association
S OzkanH Dalçik

Abstract

To investigate placental expression of insulin-like growth factor-I (IGF-I), fibroblast growth factor-basic (FGF-b) and neural cell adhesion molecule (N-CAM) regarding the pathogenesis of pregnancies with small for gestational age (SGA) fetuses. An immunohistochemical analysis using anti-IGF-I, anti-FGF-b and anti-N-CAM antibodies was carried out on 4% paraformaldehyde-fixed placental tissues of third trimester pregnancies complicated with SGA fetuses (n=12) and subjects exhibiting appropriately grown fetuses (n=10). Immunostaining patterns of chorionic villi and amniochorionic membranes were assessed. IGF-I, FGF-b and N-CAM immunostainings in chorionic villi demonstrated significantly increased immunoreactivities in cytotrophoblasts of SGA cases, whereas increased IGF-I immunostaining in syncitiotrophoblasts and increased N-CAM immunostaining in capillary endothelium were noted in the same group. IGF-I, FGF-b and N-CAM immunostainings in amniochorionic membranes revealed significantly decreased IGF-I immunoreactivities in extravillous trophoblasts and increased IGF-I immunoreactivities in decidual cells of SGA cases, while significantly decreased N-CAM immunoreactivities in both decidual cells and extravillous trophoblasts wer...Continue Reading

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Citations

Oct 22, 2013·Bulletin of Experimental Biology and Medicine·E A DubovaG T Sukhikh
Apr 24, 2010·Diagnostic Pathology·Figen BarutSukru Oguz Ozdamar
Jan 8, 2011·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Maria KoutsakiDemetrios A Spandidos
Jun 7, 2017·The Journal of Physical Chemistry. B·Meng LiChristine V Putnis
Mar 2, 2018·Biological Research for Nursing·Rungnapa RuchobAleeca F Bell
Jun 6, 2020·The Journal of Obstetrics and Gynaecology Research·Charline M SanganyThajasvarie Naicker

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