PMID: 9179920May 1, 1997Paper

Placental expression of vascular endothelial growth factor in placentae from pregnancies complicated by pre-eclampsia and intrauterine growth restriction does not support placental hypoxia at delivery

Placenta
F LyallI A Greer

Abstract

In view of the pathological placental features of pre-eclampsia and intrauterine growth restriction (IUGR), and the angiogenic effects of vascular endothelial growth factor (VEGF), the aim of this study was to determine the expression of VEGF in placentae from normal pregnancies and to compare the results with placentae from pregnancies complicated by pre-eclampsia and intrauterine growth restriction (IUGR). ELISA was used to measure circulating VEGF immunoreactivity in umbilical vein serum samples and immunohistochemistry was used to determine tissue expression of the protein. Since VEGF is known to be upregulated by hypoxia, the expression pattern of VEGF would provide further clues to the oxygen status in the placentae at the time of sampling, presently a subject under great debate. The geometric mean concentration of VEGF immunoreactivity in umbilical vein serum of normal pregnant women was 112.46 pg/ml, in women with pre-eclampsia 50.23 pg/ml and in IUGR alone 175.35 pg/ml. These values were not statistically different from each other. Immunolocalization of VEGF in normal term villous placenta was observed in the syncytiotrophoblast with less intense staining in stromal cells. No qualitative differences in localization of ...Continue Reading

References

Feb 1, 1992·American Journal of Obstetrics and Gynecology·G PardiF C Battaglia
Jul 1, 1991·British Journal of Obstetrics and Gynaecology·R PijnenborgA van Assche
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D MaglioneM G Persico
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G ConnK A Thomas
Oct 1, 1989·American Journal of Obstetrics and Gynecology·R J MorrowJ W Ritchie
Jun 15, 1989·Biochemical and Biophysical Research Communications·N Ferrara, W J Henzel
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D GospodarowiczJ Schilling
Oct 1, 1987·American Journal of Obstetrics and Gynecology·L M McCowanK Ritchie
Jan 1, 1985·British Journal of Obstetrics and Gynaecology·W B GilesP J Baird
Jan 1, 1983·British Journal of Obstetrics and Gynaecology·L NylundB Sarby
Apr 1, 1995·Placenta·T WheelerF W Anthony
Nov 1, 1993·Journal of Reproduction and Fertility·A M SharkeyS K Smith
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R L Kendall, K A Thomas
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T P QuinnL T Williams
Feb 1, 1997·British Journal of Obstetrics and Gynaecology·F LyallR Fleming
May 1, 1996·Reviews of Reproduction·F Lyall, I A Greer

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Citations

Aug 22, 2007·Archives of Gynecology and Obstetrics·Fuat AkercanNedim Karadadas
Sep 15, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J KingdomP Kaufmann
Sep 11, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Marek ZygmuntOlin D Liang
May 4, 2002·Molecular and Cellular Endocrinology·Debra Goldman-Wohl, Simcha Yagel
Feb 13, 2001·Acta Obstetricia Et Gynecologica Scandinavica·T RanheimT Henriksen
Oct 2, 2002·Clinical Endocrinology·Nigel M Page
Aug 5, 2003·Reproduction, Fertility, and Development·Kaei NasuYoshiko Tateishi
Feb 19, 2008·The Journal of Infectious Diseases·Philippe BoeufStephen J Rogerson
Jun 16, 1999·Current Opinion in Obstetrics & Gynecology·D I LebovicR N Taylor
Oct 16, 1999·British Journal of Obstetrics and Gynaecology·A ReuvekampA J Duits
May 29, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·L A SimmonsR W Jeremy
Jan 24, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Monique Y RennieJohn G Sled
Apr 24, 2010·Diagnostic Pathology·Figen BarutSukru Oguz Ozdamar
Sep 19, 2002·Journal of Perinatal Medicine·Julia WienhardMarek Zygmunt
Oct 23, 2002·American Journal of Reproductive Immunology : AJRI·Sun Ju ChoiIn-Bai Chung
May 9, 2003·Pediatric Research·Doron KreiserPhyllis A Dennery
Sep 4, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Emel KurtogluAyse Zehra Ozdemir
Jan 13, 2015·Nutrients·Song ZhangJanna L Morrison
May 17, 2008·Seminars in Perinatology·Juan A Arroyo, Virginia D Winn
Mar 14, 2007·Molecular and Cellular Endocrinology·K ReisingerM Zygmunt
Mar 12, 2005·The Journal of Physiology·Lawrence P ReynoldsJoel S Caton
Jun 17, 2004·BJOG : an International Journal of Obstetrics and Gynaecology·Eleonora SgambatiEnzo Brizzi
Jun 24, 2004·American Journal of Reproductive Immunology : AJRI·Donald S TorryRonald J Torry
Apr 4, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·M EgborP D Sibbons
Feb 24, 2010·American Journal of Reproductive Immunology : AJRI·Suzanne D BurkeB Anne Croy
Nov 20, 2012·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J Espinoza
Nov 19, 1997·Placenta·J C Kingdom, P Kaufmann
Jul 17, 2015·The Journal of Obstetrics and Gynaecology Research·Emel KurtogluSuleyman Kaplan
Nov 23, 2011·Biochemical Society Transactions·David O Bates
Sep 21, 2011·Clinical Science·Stefan VerlohrenRalf Dechend
Apr 30, 2002·Placenta·T R H RegnaultR V Anthony
Jun 19, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Selda Demircan SezerMurat Gökhan Kinaş
Jun 4, 2013·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Adi Y WeintraubMahmoud Huleihel
Nov 22, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mete CağlarSelahattin Kumru
Jan 24, 2003·Expert Opinion on Therapeutic Targets·Nigel M PagePhilip J Lowry

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