The role of placental function in maintaining an adequate fetal growth has been addressed by many different laboratories. The relationship between maternal and fetal circulation in the placenta is crucial for efficient exchanges of oxygen and nutrients. Moreover, maturational changes are taking place throughout gestation within the placenta in order to increase the transfer capacities while fetal/placental weight ratio is significantly decreasing. In human pregnancies, an impairment in the invasion of fetal trophoblast cells into the maternal decidua has been hypothesized as a cause of placental insufficiency leading to intrauterine growth restriction (IUGR). This condition has been associated with a number of adaptive changes taking place in both placenta and fetus. Adaptive changes can be followed by pathology leading to fetal death and therefore staging of the disease is fundamental for timing of delivery.A classification of the severity of IUGR in human pregnancies has been proposed based upon fetal heart rate (FHR) and Doppler velocimetry of the umbilical artery (pulsatility index or PI). This classification of clinical severity reflects different degrees of placental insufficiency and is associated with significant differ...Continue Reading
Uteroplacental arterial changes related to interstitial trophoblast migration in early human pregnancy
Na+ transport, H+ concentration gradient dissipation, and system A amino acid transporter activity in purified microvillous plasma membrane isolated from first-trimester human placenta: comparison with the term microvillous membrane
Association between the activity of the system A amino acid transporter in the microvillous plasma membrane of the human placenta and severity of fetal compromise in intrauterine growth restriction
Polarized lactate transporter activity and expression in the syncytiotrophoblast of the term human placenta
Hypoxia-inducible factor-2alpha is involved in enhanced apoptosis in the placenta from pregnancies with fetal growth restriction
Venous-arterial Doppler ratios in the prediction of acidemia at birth in pregnancies with placental insufficiency
Hypoxia in human trophoblasts stimulates the expression and secretion of connective tissue growth factor
Impact of embryo donor adiposity, birthweight and gender on early postnatal growth, glucose metabolism and body composition in the young lamb
Placental restriction increases adipose leptin gene expression and plasma leptin and alters their relationship to feeding activity in the young lamb
Serum lecithin: cholesterol acyltransferase activity, HDL2 and HDL3 composition in hypertensive mothers and their small for gestational age newborns
Placental expression of peroxisome proliferator-activated receptors in rat pregnancy and the effect of increased glucocorticoid exposure
Placental expression of secreted frizzled related protein-4 in the rat and the impact of glucocorticoid-induced fetal and placental growth restriction
The relationship between poor growth rate and increased risk of Type 2 diabetes, insulin resistance and obesity
Endothelial eNOS/arginase imbalance contributes to vascular dysfunction in IUGR umbilical and placental vessels
Placental system A amino acid transport is reduced in pregnancies with small for gestational age (SGA) infants but not in preeclampsia with SGA infants
Inability to fully suppress sterol synthesis rates with exogenous sterol in embryonic and extraembyronic fetal tissues
Melatonin improves placental efficiency and birth weight and increases the placental expression of antioxidant enzymes in undernourished pregnancy
Ductus venosus Doppler velocimetry in the prediction of acidemia at birth: which is the best parameter?
Changes in human placental oxygenation during maternal hyperoxia estimated by blood oxygen level-dependent magnetic resonance imaging (BOLD MRI)
A Cdh1HA knock-in allele rescues the Cdh1-/- phenotype but shows essential Cdh1 function during placentation
Two-dimensional and three-dimensional Doppler assessment of fetal growth restriction with different severity and onset
Are plasma total homocysteine and other amino acids associated with glucose intolerance in uncomplicated pregnancies and preeclampsia?
Elevated maternal levels of the long pentraxin 3 (PTX3) in preeclampsia and intrauterine growth restriction
Differential gene expression of somatotrophic and growth factors in response to in vivo hypoxia in human placenta
Falling insulin requirements are associated with adverse obstetric outcomes in women with preexisting diabetes
Use of Doppler velocimetry in diagnosis and prognosis of intrauterine growth restriction (IUGR): A Review
Nitric oxide synthase and changes in oxidative stress levels in embryonic kidney observed in a rabbit model of intrauterine growth restriction
N-Acetylcysteine, a glutathione precursor, reverts vascular dysfunction and endothelial epigenetic programming in intrauterine growth restricted guinea pigs
Delivery of small-for-gestational-age neonate and association with early-onset impaired maternal endothelial function
Thrombophilic-type placental pathologies and skeletal growth delay following maternal administration of angiostatin4.5 in mice
Putrescine stimulates the mTOR signaling pathway and protein synthesis in porcine trophectoderm cells
A decrease in DKK1, a WNT inhibitor, contributes to placental lipid accumulation in an obesity-prone rat model
Assessment of fetal myocardial performance in severe early onset pre-eclampsia (EO-PET) with and without intrauterine growth restriction across deteriorating stages of placental vascular resistance and links to adverse outcomes
The effects of sildenafil citrate on feto-placental development and haemodynamics in a rabbit model of intrauterine growth restriction
Matrix metalloproteinase release from placental explants of pregnancies complicated by intrauterine growth restriction
Dietary -carbamylglutamate and rumen-protected -arginine supplementation ameliorate fetal growth restriction in undernourished ewes
Biparental expression of ESX1L gene in placentas from normal and intrauterine growth-restricted pregnancies
Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep
Prolonged amino acid infusion into intrauterine growth-restricted fetal sheep increases leucine oxidation rates
Intrauterine growth restriction is associated with alterations in placental lipoprotein receptors and maternal lipoprotein composition
Placental restriction of fetal growth reduces size at birth and alters postnatal growth, feeding activity, and adiposity in the young lamb
Comparison of the fatty acid composition of maternal blood and cord blood of mothers who delivered healthy full-term babies, preterm babies, and full-term small for gestational age infants
Association between maternal vascular murmur and the small-for-gestational-age fetus with abnormal umbilical artery Doppler flow
Evaluation of the use of umbilical artery Doppler flow studies and outcome of pregnancies at a secondary hospital
TEAD4 ensures postimplantation development by promoting trophoblast self-renewal: An implication in early human pregnancy loss
Effect of oxygen concentrations on sodium iodide symporter expression and iodide uptake and hCG expression in human choriocarcinoma BeWo cells
Risk Factors for the Development of Refeeding Syndrome-Like Hypophosphatemia in Very Low Birth Weight Infants
The application of in utero magnetic resonance imaging in the study of the metabolic and cardiovascular consequences of the developmental origins of health and disease
Oxidative Stress and Neurodevelopmental Outcomes in Rat Offspring with Intrauterine Growth Restriction Induced by Reduced Uterine Perfusion.
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