Placental fractalkine is up-regulated in severe early-onset preeclampsia

The American Journal of Pathology
Monika SiwetzMartin Gauster

Abstract

The pathogenesis of preeclampsia (PE) includes the release of placental factors into the maternal circulation, inducing an inflammatory environment in the mother. One of the factors may be the proinflammatory chemokine fractalkine, which is expressed in the syncytiotrophoblast of human placenta, from where it is released into the maternal circulation by constitutive shedding. We examined whether placental fractalkine is up-regulated in severe early-onset PE and whether the proinflammatory cytokines tumor necrosis factor (TNF)-α and IL-6 are able to increase the expression of fractalkine. Gene expression analysis, enzyme-linked immunosorbent assay, and immunohistochemistry consistently showed increased fractalkine expression in placentas from severe early-onset PE, compared to gestational age-matched controls. Expression of a disintegrin and metalloproteinases (ADAMs) 10 and 17, which convert transmembrane fractalkine into the soluble form, was significantly increased in these cases. Incubation of first-trimester placental explants with TNF-α provoked a significant increase in fractalkine expression and release of the soluble form, whereas IL-6 had no effect. TNF-α-mediated up-regulation of placental fractalkine was reversed in ...Continue Reading

References

Dec 1, 1994·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R AustgulenK J Arntzen
Dec 22, 1995·Science·B Frantz, E A O'Neill
Mar 1, 1997·American Journal of Reproductive Immunology : AJRI·K P Conrad, D F Benyo
Sep 1, 1999·Acta Obstetricia Et Gynecologica Scandinavica·A E OmuM Al-Yatama
Jan 19, 2002·Hypertension·Jan Roar MellembakkenVibeke Videm
Sep 13, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Hisanori UmeharaToshio Imai
May 17, 2005·Journal of Thrombosis and Haemostasis : JTH·W C Aird
Oct 26, 2005·Placenta·S Hauguel-de Mouzon, M Guerre-Millo
Jul 11, 2006·Seminars in Fetal & Neonatal Medicine·A M BorzychowskiC W G Redman
Mar 23, 2007·Kidney International·A MakrisA Hennessy
May 5, 2007·Thrombosis and Haemostasis·Andreas Ludwig, Christian Weber
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian HundhausenAndreas Ludwig
Jun 15, 2007·American Journal of Reproductive Immunology : AJRI·Alpana SharmaJai Bhagwan Sharma
Jan 31, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pankaj K BhavsarKian Fan Chung
May 14, 2009·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Melih A GuvenHafize Oksuz
Nov 28, 2009·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Emmanuel BujoldYves Giguère
Jan 9, 2010·Expert Opinion on Therapeutic Targets·Jan G D'HaeseGüralp O Ceyhan
May 4, 2010·Placenta·S ZhaoY Wang
May 6, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Miğraci TosunErdal Malatyalioğlu
Nov 4, 2010·Molecular Interventions·Brian A JonesSalahuddin Ahmed
Jun 13, 2012·The Journal of Clinical Endocrinology and Metabolism·Yanyan YangYan-ling Wang
Jun 25, 2013·American Journal of Reproductive Immunology : AJRI·Sien Yee LauLawrence W Chamley
Aug 21, 2013·Mediators of Inflammation·Dariusz SzukiewiczTarun Kumar Mittal
Nov 26, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Dariusz SzukiewiczKrzysztof Cendrowski
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Anna Ridderstad WollbergRolf Johansson
Apr 29, 2014·Mediators of Inflammation·Monika SiwetzMartin Gauster

❮ Previous
Next ❯

Citations

Nov 12, 2015·American Journal of Reproductive Immunology : AJRI·Pinki NandiPeeyush K Lala
Jan 9, 2016·Cell Adhesion & Migration·Peeyush K Lala, Pinki Nandi
Jan 12, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Monika SiwetzMartin Gauster
Jan 18, 2017·Histochemistry and Cell Biology·Andreas ProkeschMartin Gauster
Oct 29, 2017·Cellular and Molecular Life Sciences : CMLS·Martin GausterAndreas Prokesch
Jul 28, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Akin UstaErtan Adali
Jan 5, 2019·Reproductive Sciences·S Joseph HuangCharles J Lockwood
Feb 6, 2019·International Journal of Molecular Sciences·Olivia NonnMartin Gauster
Oct 31, 2019·Stress : the International Journal on the Biology of Stress·Whitney CowellRosalind J Wright
Nov 14, 2019·International Journal of Molecular Sciences·Gerit MoserMartin Gauster
Feb 6, 2016·Journal of Cardiovascular Pharmacology·Aishah Al-Jarallah, Mabayoje A Oriowo
Dec 22, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Désirée ForstnerMartin Gauster
Oct 23, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Meydan Turan, Gulay Turan
Jan 27, 2021·Archives of Gynecology and Obstetrics·Grzegorz SzewczykAnna Fijałkowska
Feb 3, 2021·Journal of Reproductive Immunology·Jacqueline GuettlerMartin Gauster
Apr 4, 2021·International Journal of Molecular Sciences·Katarzyna PankiewiczTomasz M Maciejewski
Sep 1, 2021·PloS One·Natasha SinghMark R Johnson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Jelena MarusicDamir Roje
© 2021 Meta ULC. All rights reserved