Placental glutathione S-transferase (GST-P) induction as a potential mechanism for the anti-carcinogenic effect of the coffee-specific components cafestol and kahweol

Carcinogenesis
B SchilterA C Huggett

Abstract

The coffee specific diterpenes cafestol and kahweol (C + K) have been reported to be anti-carcinogenic in several animal models. It has been postulated that this activity may be related to their ability to induce glutathione S-transferases (GSTs). We investigated the influence of a mixture of C + K, incorporated at various levels in the diet of Sprague-Dawley rats, on the expression of different hepatic GST iso-enzymes. Liver samples were examined using isoform-specific GST substrates and antibodies, and highly selective oligomers were employed to determine effects at the RNA level. A dose-dependent increase in general GST activity was observed in male and female animals following 28 or 90 days of treatment. A time-course study demonstrated that the maximal effect was observed within 5 days of treatment. Little or no effect was found on the activity of GST alpha and mu iso-enzymes. The most striking observation was a dose-dependent induction of placental glutathione S-transferase (GST-P) which could be demonstrated at the mRNA, protein and enzymatic levels. This effect was observed in both male and female rats. The maximal induction was attained within 5 days of treatment with C + K, remained elevated with continued treatment, ...Continue Reading

Citations

May 11, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C CavinB Schilter
Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C CavinB Schilter
Sep 25, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S K Abraham, S P Singh
May 6, 1999·The New England Journal of Medicine·D S MichaudE L Giovannucci
May 9, 2008·Critical Reviews in Food Science and Nutrition·Sunitha Elizabeth GeorgeLingamallu Jagan Mohan Rao
Oct 23, 2001·Drug and Chemical Toxicology·K PremkumarA Ramesh
Oct 15, 2009·Fitoterapia·Pablo Muriel, Jonathan Arauz
Aug 15, 2008·Medical Hypotheses·Kai-Shan TaoKe-Feng Dou
Nov 7, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wolfgang W HuberRolf Schulte-Hermann
Oct 12, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey W MolloyStephen A Harrison
Feb 1, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B J MajerS Knasmüller
Jun 14, 2003·Biochemical and Biophysical Research Communications·C CavinB Schilter
Jun 9, 2004·Free Radical Biology & Medicine·Chi Chen, A-N Tony Kong
Feb 24, 2006·Nutrition Reviews·David J Homan, Sohrab Mobarhan
Jun 11, 2020·Food Research International·Marzieh Moeenfard, Arminda Alves
Dec 9, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yongfang GongYan Yang

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