Placental Growth Factor Administration Abolishes Placental Ischemia-Induced Hypertension

Hypertension
Frank T SpradleyJoey P Granger

Abstract

Preeclampsia is a pregnancy-specific disorder of new-onset hypertension. Unfortunately, the most effective treatment is early delivery of the fetus and placenta. Placental ischemia appears central to the pathogenesis of preeclampsia because placental ischemia/hypoxia induced in animals by reduced uterine perfusion pressure (RUPP) or in humans stimulates release of hypertensive placental factors into the maternal circulation. The anti-angiogenic factor soluble fms-like tyrosine kinase-1 (sFlt-1), which antagonizes and reduces bioavailable vascular endothelial growth factor and placental growth factor (PlGF), is elevated in RUPP rats and preeclampsia. Although PlGF and vascular endothelial growth factor are both natural ligands for sFlt-1, vascular endothelial growth factor also has high affinity to VEGFR2 (Flk-1) causing side effects like edema. PlGF is specific for sFlt-1. We tested the hypothesis that PlGF treatment reduces placental ischemia-induced hypertension by antagonizing sFlt-1 without adverse consequences to the mother or fetus. On gestational day 14, rats were randomized to 4 groups: normal pregnant or RUPP±infusion of recombinant human PlGF (180 μg/kg per day; AG31, a purified, recombinant human form of PlGF) for 5 ...Continue Reading

References

Dec 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D M PaternosterM Plebani
Apr 20, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A C BolteG A Dekker
Feb 7, 2004·The New England Journal of Medicine·Richard J LevineS Ananth Karumanchi
Oct 19, 2005·Hypertension·Chun LamS Ananth Karumanchi
Jul 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·M M SholookJ P Granger
Jan 5, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroS Ananth Karumanchi
Aug 2, 2008·American Journal of Hypertension·Mona SedeekJoey P Granger
Oct 15, 2008·The Journal of Experimental Medicine·Kiichiro YanoWilliam C Aird
Feb 10, 2009·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Stacey McCoy, Kathleen Baldwin
May 7, 2009·Annals of the New York Academy of Sciences·Elaine UnemoriSam L Teichman
Mar 17, 2010·American Journal of Perinatology·C David AdairJ Andrew Johnston
Jan 10, 2012·Experimental & Molecular Medicine·Sandro De Falco
Jun 15, 2012·American Journal of Physiology. Renal Physiology·Andrea SchreiberDaniel Schock-Kusch
Aug 22, 2012·Cold Spring Harbor Perspectives in Medicine·Mieke Dewerchin, Peter Carmeliet
Nov 30, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sydney R MurphyJoey P Granger
Feb 19, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Christopher T BanekJeffrey S Gilbert
Dec 18, 2013·Journal of the American Society of Nephrology : JASN·Kim M HolwerdaA Titia Lely
Aug 12, 2014·The Lancet Global Health·Lale SayLeontine Alkema
Oct 10, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Suttira IntapadBarbara T Alexander
May 8, 2015·American Journal of Epidemiology·Marika Sipola-LeppänenEero Kajantie
Jul 30, 2015·Hypertension·Fiona C BrownfootTu'uhevaha J Kaitu'u-Lino

❮ Previous
Next ❯

Citations

Oct 30, 2016·Microvascular Research·Nisha HariharanStephen Wagner
Apr 28, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hamid Reza NejabatiMohammad Nouri
Dec 16, 2016·Clinical Obstetrics and Gynecology·Sara Ornaghi, Michael J Paidas
Dec 2, 2017·BJOG : an International Journal of Obstetrics and Gynaecology·A S CerdeiraM Vatish
Apr 11, 2018·Current Hypertension Reports·Joey P GrangerBhavisha A Bakrania
Nov 9, 2017·Journal of Human Hypertension·K ChauA Makris
Nov 24, 2017·Journal of Cellular and Molecular Medicine·Yu MaPing-Jin Gao
Jun 10, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Minglin ZhuRaouf A Khalil
Nov 3, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Frank T SpradleyJoey P Granger
Apr 14, 2016·Hypertension·S Ananth Karumanchi
Apr 20, 2016·Hypertension·Lucinda M Hilliard, Kate M Denton
Sep 5, 2018·The Journal of Clinical Investigation·Jacqueline G ParchemRaghu Kalluri
Mar 7, 2018·American Journal of Physiology. Endocrinology and Metabolism·Frank T SpradleyChristopher D Anderson
Oct 20, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Wentao YuRaouf A Khalil
Nov 28, 2018·Journal of Cellular Physiology·Chunyu HeHuirong Liu
Feb 17, 2019·BJOG : an International Journal of Obstetrics and Gynaecology·J EspinozaC Yallampalli
Mar 29, 2019·Circulation Research·Sarosh RanaS Ananth Karumanchi
Apr 3, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Umit GorkemEmine Arslan
Apr 11, 2019·Journal of Developmental Origins of Health and Disease·W Tong, D A Giussani
Jan 23, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Emma J FlintManu Vatish
Dec 18, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Sarah A MarshallEuan M Wallace
Apr 6, 2019·Current Pharmaceutical Design·Emilie HitzerdA H Jan Danser
Aug 28, 2019·Clinical and Experimental Pharmacology & Physiology·Katrina ChauAngela Makris
Mar 21, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Kelsey McLaughlinJohn C Kingdom
Apr 7, 2020·Hypertension·Kathryn L GatfordAlison S Care
Jul 14, 2020·Hypertension·Edouard LecarpentierS Ananth Karumanchi
Jul 18, 2020·Geburtshilfe und Frauenheilkunde·Daniela DehardeKathrin OelmeierMurcia de
Aug 15, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuanhui JiaHao Ying
Mar 24, 2018·BioMed Research International·Nianjiao HanYoujing Dong
Feb 23, 2019·Nature Reviews. Nephrology·Elizabeth A PhippsS Ananth Karumanchi
Jan 12, 2020·Scientific Reports·Ana Sofia CerdeiraManu Vatish
Aug 27, 2018·Biology of Sex Differences·Adrian C EddyEric M George
Apr 25, 2019·Current Medical Science·Jian-Li WuLing Feng
Mar 8, 2020·Nature Reviews. Nephrology·Katsuyuki TanabeYasufumi Sato
Dec 19, 2017·Experimental and Therapeutic Medicine·Chengshu WangXianghua Huang
Nov 20, 2018·Nature Biotechnology·Anton A TuranovAnastasia Khvorova
Aug 9, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Hongmei Qu, Raouf A Khalil

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.