Placental growth factor as a predictive marker of preeclampsia - PREBIO study - PREeclampsia BIOchemical study

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Valentina GiardiniPatrizia Vergani

Abstract

To evaluate the clinical utility of placental growth factor (PlGF) for the prediction of preeclampsia (PE). This prospective cohort study included women divided into three groups: (1) pregnancies without preconceptional risk of developing PE; (2) pregnancies with a preconceptional and/or current risk of developing PE; (3) PE-complicated pregnancies (control group). Blood samples were collected every 4-5 weeks or during hospitalization from early second trimester until delivery in the group 1 and 2, at the diagnosis of PE in the group 3. Plasma levels of PlGF were measured using The Triage PlGF test (Alere) and considered pathological under the 5th centile for gestational age. Sensitivity (Sn), specificity (Sp), positive and negative predictive value (PPV, NPV) were calculated. In group 1, 30% of women (3/10) had pathological test but none of them developed PE (Sp 70%, NPV 100%). In group 2 (n = 75), none of the patients with normal test developed PE (0/24), while 39% of women with PlGF < 5th centile (20/51) developed PE (Sn 100%, Sp 44%, PPV 39%, NPV 100%). In group 3 (n = 11) all women except one had a pathological PlGF test (Sn 90%, PPV 100%). Our data support recent studies which identify PlGF as a biochemical marker not onl...Continue Reading

References

Jul 6, 2010·Journal of Pediatric Gastroenterology and Nutrition·Enrico BertinoSilvano Milani
Sep 21, 2011·Clinical Science·Stefan VerlohrenRalf Dechend
Sep 1, 2014·Metabolism: Clinical and Experimental·Makarios EleftheriadesGeorge P Chrousos
Oct 21, 2014·The Journal of Clinical Investigation·S Lee Adamson
Sep 8, 2015·Lancet·Ben W J MolG Justus Hofmeyr
Oct 1, 2015·Fetal Diagnosis and Therapy·Beatrice MosimannLuigi Raio
Oct 3, 2015·American Journal of Obstetrics and Gynecology·Christopher W G Redman, Anne Cathrine Staff
Jan 7, 2016·The New England Journal of Medicine·Harald ZeislerStefan Verlohren
Feb 26, 2016·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S J GordijnW Ganzevoort
Jun 15, 2016·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M VatishC Smare
Jan 31, 2017·Placenta·Lynne S Cox, Christopher Redman
Sep 20, 2017·Medical Journal, Armed Forces India·Kavita SahaiManu Krishnan

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Citations

Mar 9, 2021·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Ge SunJing Shao

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