Placental Growth Factor as a Predictor of Cardiovascular Events in Patients with CKD from the NARA-CKD Study

Journal of the American Society of Nephrology : JASN
Masaru MatsuiNARA-CKD Investigators

Abstract

Placental growth factor (PlGF) contributes to atherogenesis through vascular inflammation and plaque destabilization. High levels of PlGF may be associated with mortality and cardiovascular disease, but the relationship between PlGF level and adverse outcomes in patients with CKD is unclear. We conducted a prospective cohort study of 1351 consecutive participants with CKD enrolled in the Novel Assessment of Risk management for Atherosclerotic diseases in CKD (NARA-CKD) study between April 1, 2004, and December 31, 2011. During a median follow-up of 3 years, 199 participants died and 383 had cardiovascular events, defined as atherosclerotic disease or heart failure requiring hospitalization. In adjusted analyses, mortality and cardiovascular risk increased in each successive quartile of serum PlGF level; hazard ratios (HRs) (95% confidence intervals [95% CIs]) for mortality and cardiovascular risk, respectively, were 1.59 (0.83 to 3.16) and 1.55 (0.92 to 2.66) for the second quartile, 2.97 (1.67 to 5.59) and 3.39 (2.20 to 5.41) for the third quartile, and 3.87 (2.24 to 7.08) and 8.42 (5.54 to 13.3) for the fourth quartile. The composite end point of mortality and cardiovascular events occurred during the study period in 76.4% of...Continue Reading

References

Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D MaglioneM G Persico
Oct 1, 1993·Journal of the American College of Cardiology·K K HoD Levy
Sep 17, 1998·The New England Journal of Medicine·C A HerzogA J Collins
Jul 31, 2001·JAMA : the Journal of the American Medical Association·H C GersteinUNKNOWN HOPE Study Investigators
Jan 25, 2003·Annals of the New York Academy of Sciences·Aernout LuttunPeter Carmeliet
Jan 30, 2004·JAMA : the Journal of the American Medical Association·Yongmei LiuMichael J Klag
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Jan 18, 2006·Journal of the American College of Cardiology·Timo LenderinkUNKNOWN CAPTURE Investigators
Oct 18, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Aedín CassidyEric B Rimm
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
Jun 6, 2009·Journal of the American College of Cardiology·Fadi G HageAmi E Iskandrian
Dec 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A Craig LockhartWilliam P Tew
Dec 22, 2009·Nature Reviews. Nephrology·Sadayoshi Ito
Feb 4, 2010·JAMA : the Journal of the American Medical Association·Brenda R HemmelgarnUNKNOWN Alberta Kidney Disease Network
Feb 18, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Masafumi SakumaAkira Okayama
Apr 27, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Masaru HorioSeiichi Matsuo
Oct 6, 2010·The Journal of Clinical Investigation·Iris Z JaffeMichael E Mendelsohn
Mar 18, 2011·Kidney International·Jean-Philippe BertocchioFrederic Jaisser
Jun 16, 2011·JAMA : the Journal of the American Medical Association·Tamara IsakovaUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study Group
Oct 8, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Julia SearleFlorian Herse
May 10, 2012·JAMA : the Journal of the American Medical Association·Kunihiro MatsushitaUNKNOWN Chronic Kidney Disease Prognosis Consortium
Mar 23, 2013·Journal of the American Society of Nephrology : JASN·Julie R DominguezJoachim H Ix

❮ Previous
Next ❯

Citations

Dec 28, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuki NakadaYoshihiko Saito
Jul 1, 2020·Nature Reviews. Endocrinology·John D AplinMelissa Westwood
Oct 13, 2020·Journal of Molecular and Cellular Cardiology·Yoshihiko Saito
Feb 16, 2021·Frontiers in Immunology·Oluwabukola T GbotoshoGregory J Kato
Apr 9, 2019·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sherry G MansourUNKNOWN TRIBE-AKI Consortium

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

Clinical Journal of the American Society of Nephrology : CJASN
James RitchiePhilip A Kalra
Journal of the American Society of Nephrology : JASN
Julia J SciallaChronic Renal Insufficiency Cohort (CRIC) Study Investigators
Journal of the American Society of Nephrology : JASN
Casey M RebholzChronic Kidney Disease Biomarkers Consortium
© 2021 Meta ULC. All rights reserved