Placental growth factor as an indicator of fetal growth restriction in late-onset small-for-gestational age pregnancies

The Australian & New Zealand Journal of Obstetrics & Gynaecology
Ngaire AndersonLesley M McCowan

Abstract

At-risk small-for-gestational age (SGA) pregnancies in New Zealand are identified using Doppler ultrasound; fetuses with Doppler abnormalities are considered growth restricted (FGR). Low maternal placental growth factor (PlGF) has also been associated with late-onset FGR. To investigate whether low PlGF at diagnosis of late-onset SGA identifies the same fetuses classified FGR by detailed Doppler studies, and the association between low PlGF and adverse pregnancy outcomes. Among an historical database of normotensive suspected SGA pregnancies (fetal abdominal circumference <10th percentile) ≥32 weeks gestation, the ability of low PlGF (<5th percentile) to identify FGR infants was investigated. 'Initial FGR' was an abnormal umbilical artery resistance index (RI) or estimated fetal weight <3rd customised centile. 'Secondary FGR' was abnormal internal carotid RI, cerebro-placental ratio and/or mean uterine artery RI. Development of hypertensive disease and adverse perinatal outcomes were compared by PlGF status. Of 136 SGA pregnancies, 56 (41.1%) had initial FGR. Of the remaining, 20 (25.0%) had secondary FGR, 17 (21.3%) low PlGF. The sensitivity of low PlGF identifying secondary FGR was 0.30 (95% CI 0.14-0.50), specificity 0.83 (0...Continue Reading

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Citations

Dec 12, 2018·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Stephanie Beresford
Sep 19, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·D Hayes-RyanK O'Donoghue
Sep 21, 2020·Journal of Ayurveda and Integrative Medicine·Salehoddin BouyaKhadije Rezaie Keikhaie

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