Placental heat shock proteins: no immunohistochemical evidence for a differential stress response in preterm labour

Gynecologic and Obstetric Investigation
M J DiversR J Lilford

Abstract

The aetiology of idiopathic preterm labour remains obscure. The hypothesis that a stress response induced by low-grade bacterial infection in utero-placental tissues was investigated. Distribution of cognate and inducible isoforms of heat shock proteins (HSP) 70 kD, HSP 60 kD and HSP 90 kD were investigated in an immunohistochemical study of placental and decidual tissues before and after labour at varying gestations. Subjects were pregnant women undergoing singleton delivery after idiopathic preterm labour at less than 34 weeks' gestation (n = 23); spontaneous term labour at 37-42 weeks' gestation (n =24); preterm caesarean sections at less than 34 weeks' gestation for preeclampsia or intrauterine growth retardation (n=14); elective caesarean section at 37-42 weeks' gestation for cephalopelvic disproportion (n = 6). HSP expression was constant throughout the third trimester of pregnancy and did not change following the onset of labour, regardless of gestational age. A stress response in decidual tissues as determined by immunohistochemical analysis is apparently not associated with preterm labour.

Citations

Oct 13, 2009·Cell Stress & Chaperones·Attila MolvarecJános Rigó
Mar 17, 2009·Reproductive Biology and Endocrinology : RB&E·Jin-Xiang YuanYi-Xun Liu
Feb 14, 2007·Journal of Reproductive Immunology·Attila MolvarecZoltán Prohászka
Feb 25, 2009·American Journal of Reproductive Immunology : AJRI·Ivelina MinevaLudwig Wagner
Dec 10, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·C P James
Dec 10, 2016·The Indian Journal of Medical Research·Ilona HromadnikovaLadislav Krofta
Jan 10, 2012·Gynecologic and Obstetric Investigation·Aykut BarutBanu Dogan Gun
Jul 5, 2005·Obstetrics and Gynecology·Liisa KarinenAnna-Liisa Hartikainen
May 1, 2007·Proteomics. Clinical Applications·Rose P WebsterLeslie Myatt
Jun 24, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tinnakorn ChaiworapongsaRoberto Romero
Aug 17, 1999·Infectious Diseases in Obstetrics and Gynecology·M ZiegertW Härtig
Jan 27, 2005·The Journal of Obstetrics and Gynaecology Research·Akimune FukushimaSaburo Horiuchi
May 18, 2021·Frontiers in Cell and Developmental Biology·Babban JeeSubhradip Karmakar

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