Placental lesions associated with oligohydramnios in fetal growth restricted (FGR) pregnancies

Placenta
Arsenio SpinilloEnrico Silini

Abstract

Aim of the study was to investigate the association between placental pathology and oligohydramnios in pregnancies complicated by fetal growth restriction (FGR). Placentas from 221 consecutive FGR pregnancies and 63 healthy controls were studied. Pathological lesions were described according to consensus nomenclature and standardized criteria; both elementary lesions and constellations of lesions (patterns) were considered. Statistics included analysis of linear trends and multinomial logistic regression. Amniotic fluid index (AFI) was normal in 56 (25.3%) FGR pregnancies, whereas mild, moderate and severe oligohydramnios were diagnosed in 32 (14.5%), 44 (19.9%) and 89 (40.3%) subjects, respectively. In FGR pregnancies, after adjustment for potential confounders, membrane meconium staining (chi-square = 28.6, p < 0.001), chronic villous hypoxia pattern (chi-square = 18.8, p < 0.001) and fetal thrombotic vasculopathy pattern (chi-square = 9.2, p = 0.002) were positively and linearly correlated to AFI decrease. Odds ratios of meconium and chronic villous hypoxia were 9.2 (95% CI = 2.6-32.9) and 4.2 (95% CI = 1.3-13.6) in FGR pregnancies with normal AFI and 25.2 (95% CI = 6.9-91.8) and 9.7 (95% CI = 3-31.5) in those with severe ol...Continue Reading

References

Feb 1, 1987·Journal of Clinical Ultrasound : JCU·T TodrosS Zucca
Nov 5, 1997·Obstetrics and Gynecology·A SpinilloA Ferrari
Dec 22, 1999·American Journal of Obstetrics and Gynecology·S P ChauhanL D Devoe
Dec 2, 2005·Obstetrics and Gynecology·Erich CosmiGiancarlo Mari
Jan 13, 2006·Journal of Perinatology : Official Journal of the California Perinatal Association·J A HenryT D Yanowitz
Jan 27, 2007·Placenta·M H BeallM G Ross
Feb 17, 2007·Placenta·M H BeallM G Ross
May 5, 2010·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Aasia SaleemuddinMana M Parast

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Citations

Oct 27, 2015·The Journal of Physiology·Dino A Giussani
Dec 19, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gayatri RavikumarTirumalai Srinivas Sridhar
Dec 15, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Alex RabinovichOffer Erez
Jan 26, 2018·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·D GüvenI Kocak
Aug 6, 2019·The Journal of Obstetrics and Gynaecology Research·Takashi IizukaHiroshi Fujiwara

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