Placental mesenchymal stem cells as potential autologous graft for pre- and perinatal neuroregeneration

American Journal of Obstetrics and Gynecology
C Bettina Portmann-LanzDaniel V Surbek

Abstract

Mesenchymal stem cells (MSCs) have a broad differentiation potential. We aimed to determine if MSCs are present in fetal membranes and placental tissue and to assess their potential to differentiate into neurogenic and mesodermal lineages. MSCs isolated from first and third trimester chorion and amnion and first trimester chorionic villi and characterized morphologically and by flourescence-activated cell sorting analysis. Their ability to mature under different culture conditions into various cells of mesodermal and neuroectodermal cell lines was assessed by immuno- and cytochemical staining. Independent of gestational age, cells isolated from fetal membranes and placenta showed typical MSC phenotype (positive for CD166, CD105, CD90, CD73, CD49e, CD44, CD29, CD13, MHC I; negative for CD14, CD34, CD45, MHC II) and were able to differentiate into mesodermal cells expressing cell markers/cytologic staining consistent with mature chondroblasts, osteoblasts, adipocytes, or myocytes and into neuronal cells presenting markers of various stages of maturation. The differentiation pattern was mainly dependent on cell type. Mesenchymal cells from chorion, amnion, and villous stroma can be differentiated into neurogenic, chondrogenic, ost...Continue Reading

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Citations

Apr 11, 2008·Cell and Tissue Research·Zuzana StrakovaIvanna Ihnatovych
Nov 13, 2008·Cytotechnology·Marco EvangelistaOrnella Parolini
Sep 6, 2011·Stem Cell Reviews and Reports·Mohamed AbumareeBill Kalionis
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Jun 11, 2008·Human Reproduction·Jeong Hee MoonHae Kwon Kim
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Aug 27, 2010·Journal of the Royal Society, Interface·Hassan AbdulrazzakPascale V Guillot
Jul 19, 2011·Journal of Biomedical Science·Pei-Min ChenB-Linju Yen
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Jan 1, 2009·Reviews in the Neurosciences·Sergey V Anisimov
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Dec 12, 2013·Cell and Tissue Banking·Julia KönigBerthold Huppertz
May 16, 2014·Cell and Tissue Banking·Andrea LindenmairSusanne Wolbank

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