Placental morphology of rats prenatally exposed to methyl parathion

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
M Levario-CarrilloEstela Bevilacqua

Abstract

Although prenatal exposure to pesticides has been associated with numerous adverse reproductive effects, data on the effects of such toxics in the placenta is limited. Thus, the present study was carried out to determine the morphology of the rat placenta exposed to the organophosphate pesticide methyl parathion (MP) in ad libitum fed and restricted diet animals. The pregnant females were randomly divided into control groups and experimental groups, the latter of which received MP at the doses of 0.0, 1.0, 1.5 and 2.0 mg/kg. Most cells in the maternal-fetal interface showed significant alterations in the presence of MP. Trophoblast giant cells exhibited either prominent characteristics of degeneration or normal morphology with many phagosome vacuoles, apparently containing cell debris. Vascular congestion was also more frequent in the labyrinth of the treated animals. Areas of fibrosis and hemorrhage were found in the decidua, as well as decidual cells presenting pyknotic nuclei and acidophilic cytoplasm. In the placentas of females treated with both restricted diet and MP, such changes were much more severe. Together, these alterations suggest a direct, toxic effect of MP on the placental cells. The phagocytic activity exhibit...Continue Reading

References

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Citations

Jul 5, 2006·International Journal of Environmental Research and Public Health·Falicia L Edwards, Paul B Tchounwou
Jan 23, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Marlon EspinozaNatalia Guiñazú
Jan 24, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Natalia GuiñazúGladis Magnarelli
Dec 14, 2011·Toxicology Letters·Claude SchummerBrice M R Appenzeller
Feb 1, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sükran Cakir, Rabia Sarikaya
Sep 5, 2015·BioMed Research International·Daniela Sarahí Gutiérrez-TorresBlanca Sánchez-Ramírez
Oct 19, 2011·Toxicology Mechanisms and Methods·M Sánchez-GuerraB Quintanilla-Vega
Jul 25, 2008·Human & Experimental Toxicology·B González-GarcíaB Sánchez-Ramírez
Jun 10, 2010·Folia Histochemica Et Cytobiologica·Franciszek BurdanRobert Klepacz
Feb 12, 2019·Journal of Toxicologic Pathology·Satoshi FurukawaAkihiko Sugiyama
Nov 19, 2020·Anais Da Academia Brasileira De Ciências·Jaqueline N DA SilvaAna Paula A Favareto
Jun 2, 2021·Environmental Science and Pollution Research International·Amalia CecchiMaría Gabriela Rovedatti

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