Oct 10, 1977

Placental origin of the progesterone binding protein in the pregnant guinea pig; immunohistoligical study

Comptes rendus hebdomadaires des séances de l'Académie des sciences. Série D: Sciences naturelles
B MetzE M Chambaz

Abstract

The origin of the high affinity progesterone binding protein (PBP) occurring during pregnancy in the guinea pig serum has been investigated. An indirect immunofluorescence technique has been developed using a specific antiserum raised in rabbits. An accumulation of PBP-like immunofluorescent material was detected in the trophoblastic syncytium of the placenta tissue, whereas all other examined pregnant guinea pig organs gave negative reactions. It is concluded that this placental accumulation of immunoreactive PBP-like material may express a placental biosynthesis of this glycoprotein.

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Mentioned in this Paper

Immunofluorescence Assay
Giant Cells
Placenta Specimen
Cavia
Glycoproteins
Immune Sera
Placenta
Organ
Entire Placenta
Eutheria

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