Placental pathology, corticotropin-releasing hormone, timing of parturition, and fetal growth in the pregnancy outcomes and community health study

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Wei PerngPatricia K Senagore

Abstract

Background: Identification of vascular pathologies in delivered placentas and their associations with biomarkers measured during pregnancy may elucidate mechanisms of adverse pregnancy outcomes and inform early detection and intervention strategies.Objectives: To examine associations of placental vascular pathology with birth size and timing of parturition, and to evaluate maternal midpregnancy serum corticotropin-releasing hormone (CRH) levels as a marker of the above associations.Study design: The pregnancy outcomes and community health (POUCH) Study enrolled women at 16-27 weeks of pregnancy from five Michigan communities. Histological assessments of delivered placentas and assays of CRH in maternal blood sampled at enrollment were performed in a subcohort of 1152 participants. Five placental vascular pathology constructs were formulated: Maternal-Vascular-Obstructive (MVO), Fetal Vascular-Obstructive (FVO), Maternal Vascular-disturbance of Integrity (MVI), Fetal Vascular-disturbance of Integrity (FVI), and Maternal Vascular-Developmental (MVD). A four-level outcome variable combined small for gestational (SGA) yes/no and delivery timing preterm/term; the non-SGA/term served as the referent group. In multinomial logistic reg...Continue Reading

References

Apr 1, 1992·American Journal of Obstetrics and Gynecology·W B WarrenR S Goland
Oct 1, 1995·American Journal of Obstetrics and Gynecology·C M SalafiaA M Vintzileos
Sep 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·A FerrariE Gurpide
Nov 5, 1997·Obstetrics and Gynecology·A GhidiniJ C Pezzullo
May 20, 1998·The Journal of Clinical Endocrinology and Metabolism·C KorebritsJ R Challis
Nov 7, 1999·Lancet·D K Grammatopoulos, E W Hillhouse
Nov 30, 1999·JAMA : the Journal of the American Medical Association·C V AnanthR H Lapinski
Nov 21, 2000·Obstetrics and Gynecology·R A OdegårdR Austgulen
Aug 25, 2001·Paediatric and Perinatal Epidemiology·C HolzmanUNKNOWN Prematurity Study Group
Apr 24, 2002·Placenta·D M O BecroftE A Mitchell
Sep 11, 2002·Regulatory Peptides·Roger SmithShaun McGrath
May 9, 2003·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·D OgunyemiB Alperson
Sep 29, 2004·Early Human Development·Mei Yee ChoyTze K Lau
Oct 28, 2004·American Journal of Obstetrics and Gynecology·Pathik D WadhwaCurt A Sandman
Aug 25, 2005·American Journal of Public Health·Terry J RosenbergMary Ann Chiasson
May 9, 2008·The New England Journal of Medicine·UNKNOWN HAPO Study Cooperative Research GroupDavid A Sacks
Nov 18, 2008·Diabetes·UNKNOWN HAPO Study Cooperative Research Group
Jun 11, 2009·American Journal of Epidemiology·R KellyH Chung
Aug 13, 2011·Diabetology & Metabolic Syndrome·Marilza Vc RudgeIracema Mp Calderon
Oct 1, 2011·Journal of Developmental Origins of Health and Disease·N M TalgeR Fisher
Oct 23, 2013·American Journal of Obstetrics and Gynecology·Jerzy Stanek
Dec 18, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Raed SalimGali Garmi
Oct 14, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yeon Mee KimSteven J Korzeniewski

❮ Previous
Next ❯

Citations

Oct 9, 2021·Cell Communication and Signaling : CCS·Megan C ShepherdRamkumar Menon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.