Placental Pathology in COVID-19.

American Journal of Clinical Pathology
Elisheva D ShanesJeffery A Goldstein


To describe histopathologic findings in the placentas of women with coronavirus disease 2019 (COVID-19) during pregnancy. Pregnant women with COVID-19 delivering between March 18, 2020, and May 5, 2020, were identified. Placentas were examined and compared to historical controls and women with placental evaluation for a history of melanoma. Sixteen placentas from patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were examined (15 with live birth in the third trimester, 1 delivered in the second trimester after intrauterine fetal demise). Compared to controls, third trimester placentas were significantly more likely to show at least one feature of maternal vascular malperfusion (MVM), particularly abnormal or injured maternal vessels, and intervillous thrombi. Rates of acute and chronic inflammation were not increased.The placenta from the patient with intrauterine fetal demise showed villous edema and a retroplacental hematoma. Relative to controls, COVID-19 placentas show increased prevalence of decidual arteriopathy and other features of MVM, a pattern of placental injury reflecting abnormalities in oxygenation within the intervillous space associated with adverse perinatal outcomes. Only 1 COVID-19 p...Continue Reading


Jan 1, 1989·Placenta·A G GarciaY Y Lobato
Jan 1, 1984·Archives of Pathology & Laboratory Medicine·G Altshuler
Jan 1, 1995·Reproduction, Fertility, and Development·H SomaT Hata
Oct 31, 2003·American Journal of Obstetrics and Gynecology·Julie S MoldenhauerBaha Sibai
Jul 17, 2004·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·David M O BecroftEdwin A Mitchell
Feb 8, 2005·American Journal of Obstetrics and Gynecology·Raymond W Redline
Apr 3, 2008·Acta Obstetricia Et Gynecologica Scandinavica·George DaskalakisAris Antsaklis
Jul 19, 2008·Pathology, Research and Practice·Metin AkbulutEnder Duzcan
Apr 13, 2011·Virchows Archiv : an International Journal of Pathology·Sangeeta PathakChristoph Lees
Oct 18, 2011·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Christiane Fernandes RibeiroRita Maria Ribeiro Nogueira
May 26, 2016·Archives of Pathology & Laboratory Medicine·T Yee KhongSanne J Gordijn
Jul 1, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Abdullah AssiriJohn T Watson
Jul 4, 2016·Lancet·Roosecelis Brasil MartinesSherif R Zaki
Aug 16, 2017·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Linda M ErnstEmily S Miller
Sep 7, 2017·Journal of Korean Medical Science·Soo Young JeongJong Hwa Kim
Dec 23, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Athena Chen, Drucilla J Roberts
Jul 26, 2018·Journal of Perinatal Medicine·Roberto RomeroOffer Erez
May 12, 2019·Virchows Archiv : an International Journal of Pathology·Jane Esther Dahlstrom
Dec 11, 2019·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Alexa A FreedmanLinda M Ernst
Feb 14, 2020·Current Alzheimer Research·Zhongke GaoUNKNOWN Alzheimer’s DiseaseNeuroimaging Initiative
Mar 19, 2020·AJR. American Journal of Roentgenology·Dehan LiuChuansheng Zheng
Mar 19, 2020·The New England Journal of Medicine·Xiaoxia LuUNKNOWN Chinese Pediatric Novel Coronavirus Study Team
Apr 8, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Mehreen Zaigham, Ola Andersson
Apr 16, 2020·American Journal of Obstetrics & Gynecology MFM·Daniele Di MascioFrancesco D'Antonio
Apr 16, 2020·The Journal of Infection·Hui YangZhichun Jin
May 1, 2020·JAMA : the Journal of the American Medical Association·David BaudLéo Pomar
May 6, 2020·Intensive Care Medicine·Julie HelmsUNKNOWN CRICS TRIGGERSEP Group (Clinical Research in Intensive Care and Sepsis Trial Group for Global Evaluation and Research in Sep

❮ Previous
Next ❯


Jun 14, 2020·American Journal of Clinical Pathology·Rebecca N BaergenJeffery A Goldstein
Jun 24, 2020·American Journal of Physiology. Endocrinology and Metabolism·Thea N Golden, Rebecca A Simmons
Jul 23, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Melis Deniz, Hasan Tezer
Jul 18, 2020·American Journal of Reproductive Immunology : AJRI·Sonam VermaIndira U Mysorekar
Aug 25, 2020·Zeitschrift für Geburtshilfe und Neonatologie·Janine ZöllkauEkkehard Schleußner
Aug 30, 2020·Annals of the New York Academy of Sciences·Elizabeth Centeno-TablanteSaurabh Mehta
Aug 28, 2020·American Journal of Human Biology : the Official Journal of the Human Biology Council·Theresa E Gildner, Zaneta M Thayer
Sep 6, 2020·Journal of the Pediatric Infectious Diseases Society·Ihab AlamarBeata Dygulska
Sep 25, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Romolo Di IorioGiuseppe Benagiano
Aug 1, 2020·Frontiers in Immunology·Ricardo Wesley AlbercaMaria Notomi Sato
Jul 25, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Galit H FrydmanGregory Piazza
Aug 25, 2020·Der Gynäkologe·C HagenbeckJ Zöllkau
Sep 23, 2020·Journal of Assisted Reproduction and Genetics·Wafaa EssahibHilde Van de Velde
Aug 4, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jonathon L HechtDrucilla J Roberts
Sep 15, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Charmaine YamRuth Dobson
Sep 16, 2020·Open Forum Infectious Diseases·Katelyn A PastickEmily G McDonald
Jun 18, 2020·International Journal of Environmental Research and Public Health·Álvaro Francisco Lopes de SousaInês Fronteira
Oct 10, 2020·Journal of Perinatal Medicine·Yalda AfsharLawrence D Platt
Oct 1, 2020·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·P Vigil-De GraciaJ Ng C
Jul 19, 2020·Journal of Perinatal Medicine·Tuangsit WataganaraKusol Russameecharoen
Aug 5, 2020·Journal of Medical Virology·Albert L HsuXiu-Feng Wan
Nov 11, 2020·Journal of Developmental Origins of Health and Disease·Molly Crimmins EasterlinCaleb E Finch
Nov 12, 2020·Human Vaccines & Immunotherapeutics·Kranti Suresh VoraSenthilkumar Natesan
Nov 24, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·M MendozaA Suy
Nov 28, 2020·Maternal and Child Health Journal·Jennifer Prince KingsleyNalini Sathiakumar
Dec 18, 2020·Frontiers in Public Health·Carina RodriguesHenrique Barros
Jul 14, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Matthieu Dap, Olivier Morel
Aug 3, 2020·American Journal of Obstetrics and Gynecology·Alexander M KotlyarReshef Tal
Jan 15, 2021·Diagnostic Pathology·Likun GaoJingping Yuan
Nov 3, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Walter Orlando Beys-da-SilvaMarkus Berger
Nov 30, 2020·Journal of Reproductive Immunology·Marcelo Borges CavalcanteJoanne Kwak-Kim
Dec 15, 2020·International Journal of Antimicrobial Agents·Zheng HeDong Liu
Jan 30, 2021·Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia·Bruno Ramalho de CarvalhoAlessandra Cristina Marcolin
Aug 5, 2020·Human Pathology·Walter O Vasquez-BonillaAlfonso J Rodríguez-Morales
Feb 12, 2021·Current Hypertension Reports·Rowen GovenderThajasvarie Naicker

❮ Previous
Next ❯

Methods Mentioned


Software Mentioned

Natural Language Toolkit ( NLTK )

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

MedRxiv : the Preprint Server for Health Sciences
Elisheva D ShanesJeffery A Goldstein
MedRxiv : the Preprint Server for Health Sciences
Elisheva D ShanesJeffery A Goldstein
APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Linda M Ernst
© 2021 Meta ULC. All rights reserved