Placental protein 13: An important biological protein in preeclampsia

Journal of Circulating Biomarkers
Ranjeeta GaddeS R Sheela

Abstract

Placental protein 13 (PP13), a glycan binding protein predominantly expressed in syncytiotrophoblast, dimeric in nature, lacks N-terminal signal peptide, bypasses the endoplasmic reticulum, and secretes into maternal circulation as exosomes or microvesicles. PP13 has jelly roll fold conformation with conserved carbohydrate recognition domain which specifically binds to β-galactosides of the glycan receptors during placentation. PP13 binds to glycosylated receptors on human erythrocytes and brings about hemagglutination by the property of lectin activity; other functions are immunoregulation and vasodilation during placentation and vascularization. The gene LGALS13 located on 19q13.2 comprising four exons expresses a 32-kDa protein with 139 amino acid residues, PP13. Impaired expression due to mutation in the gene leads to a nonfunctional truncated PP13. The low serum levels predict high risk for the onset of preeclampsia or obstetric complications. Hence, PP13 turned to be an early marker for risk assessment of preeclampsia. The recombinant PP13 and monoclonal antibodies availability help for replenishing PP13 in conditions with low serum levels and for detection and prevention of preeclampsia, respectively.

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Citations

Mar 7, 2019·Current Medicinal Chemistry·N S DasD K Srinivasan
Oct 27, 2020·European Journal of Obstetrics & Gynecology and Reproductive Biology: X·Nan LiuBing-Shun Wang
Jul 10, 2021·Mediators of Inflammation·Zengfang WangXue Liu
Oct 16, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Raquel L MartinLaura M Vargas-Roig

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