Placental protein 13 (PP13)-induced vasodilation of resistance arteries from pregnant and nonpregnant rats occurs via endothelial-signaling pathways

Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy
Tijana DrobnjakGeorge Osol

Abstract

Placental protein 13 (PP13) induces hypotension in rats. This study aims to evaluate PP13 effects on isolated uterine arteries from nonpregnant and mid-pregnant rats. Vessels were isolated, cannulated, and pressurized to 50 mmHg within an arteriograph, preconstricted and exposed to increasing PP13 concentrations (10-13-10-8M). PP13 elicited 38-50% arterial vasodilation with half-maximum response (EC50) = 1 pM. The relaxation was mediated by activating the endothelial-signaling pathways of prostaglandin and nitric oxide (NO). Accordingly, these results encourage evaluation of PP13 as a possible therapy for gestational diseases characterized by insufficient uteroplacental blood flow and/or maternal hypertension.

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Citations

Mar 27, 2019·Integrative and Comparative Biology·Timothy E HighamThomas Speck
Jun 30, 2019·International Journal of Molecular Sciences·Helmut K LacknerManfred G Moertl
Jul 3, 2019·International Journal of Molecular Sciences·Marei SammarHamutal Meiri
Dec 21, 2018·Archives of Gynecology and Obstetrics·Ron MaymonHoward Cuckle
Jul 20, 2018·Journal of Circulating Biomarkers·Ranjeeta GaddeS R Sheela
Jun 25, 2019·Frontiers in Immunology·Sandra M BloisGabriela Barrientos
Jul 6, 2019·Frontiers in Immunology·Andrea BaloghNandor Gabor Than
Jul 1, 2020·Seminars in Immunopathology·Sandra M BloisGabriela Barrientos
Dec 16, 2018·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Berthold Huppertz

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