Placental restriction alters circulating thyroid hormone in the young lamb postnatally

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Miles J De BlasioJulie A Owens

Abstract

Intrauterine growth restriction (IUGR) is associated with accelerated growth and increased adiposity in early life due to unknown mechanisms, which could include increased thyroid hormone (TH) action. We hypothesized that placental restriction (PR) of fetal growth would increase circulating TH concentrations and alter their response to fasting, and that these would relate to growth and body composition in the young lamb. PR reduced size at birth, increased fractional growth rates (FGRs) of soft and skeletal tissues up to 30 days of age, and slowed the ontogenic decrease in plasma total T3 and plasma total T3/T4. PR did not alter the abundance of plasma THs after short-term fasting. In general, plasma total T3 and total T3/T4 ratio correlated negatively, whereas plasma total T4 correlated positively with size at birth. Absolute growth rates of weight and crown-rump length correlated positively with plasma total T3 and total T4 between days 15 and 35. Current FGRs for weight and metatarsal length correlated positively with plasma total T3 between days 20 and 35. In conclusion, PR and small size at birth reduce plasma total T4 and increase plasma total T3 postnatally, whereas catch-up growth relates to increased abundance of the m...Continue Reading

References

Jan 1, 1989·Reproduction, Nutrition, Development·G Cabello, C Wrutniak
Jan 1, 1989·Acta Paediatrica Scandinavica. Supplement·P M Fitzhardinge, S Inwood
Jan 1, 1985·Acta Paediatrica Scandinavica. Supplement·J S RobinsonJ A Owens
Dec 1, 1984·European Journal of Pediatrics·J J Bongers-Schokking, W Schopman
Aug 1, 1995·Pediatric Research·A C Hokken-KoelegaS L Drop
Oct 1, 1995·Archives of Disease in Childhood·C H FallD J Barker
Apr 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·C S YajnikD J Barker
May 1, 1993·Acta Paediatrica·K Albertsson-WiklandS Rosberg
Nov 1, 1995·Pediatric Research·J Karlberg, K Albertsson-Wikland
May 1, 1996·Journal of Endocrinological Investigation·Z KmiecA Mysliwski
Aug 1, 1997·Australian and New Zealand Journal of Public Health·D RoderA Chan
Dec 24, 1997·Acta Paediatrica. Supplement·A LapillonneB L Salle
Feb 12, 1999·BMJ : British Medical Journal·J G ErikssonD J Barker
Jun 22, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·S CianfaraniF Branca
Jan 15, 2000·Early Human Development·L McCowanC Ford
Dec 16, 2000·Biological Reviews of the Cambridge Philosophical Society·A J Hulbert
Jun 28, 2001·Physiological Reviews·P M Yen
Jan 12, 2002·Hormone Research·P M StewartJ W Tomlinson
Feb 1, 2002·International Journal of Epidemiology·C G VictoraR Martorell
Apr 3, 2002·The Journal of Endocrinology·K L GatfordJ A Owens
Mar 13, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·François CasasChantal Wrutniak-Cabello
Jun 25, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·I Rogers, UNKNOWN EURO-BLCS Study Group
Aug 6, 2003·Annals of Internal Medicine·John D Rowlett
Apr 23, 2005·The Journal of Endocrinology·S Van der Geyten, V M Darras

❮ Previous
Next ❯

Citations

Apr 20, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Leticia E CamachoKimberly A Vonnahme
Sep 1, 2007·The Journal of Physiology·Julie A OwensAbigail L Fowden
Dec 17, 2014·The Veterinary Quarterly·E FazioP Medica
Jun 12, 2016·Physiology & Behavior·Damien S HunterKathryn L Gatford
Oct 7, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Miles J De BlasioJulie A Owens
Mar 1, 2007·American Journal of Physiology. Endocrinology and Metabolism·J A OwensK L Gatford
Mar 1, 2010·Expert Review of Endocrinology & Metabolism·Jane E HardingFrank H Bloomfield
Mar 14, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Xiaoya ZhengYonghong Wang
Jan 26, 2021·Frontiers in Neuroendocrinology·Maurice PagninMary Tolcos
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.