Placental site trophoblastic tumor in a patient with brain and lung metastases

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
E S Guvendag GuvenA Usubutun

Abstract

Placental site trophoblastic tumor is a rare neoplasm that arises from intermediate trophoblasts and shows diversity of biological behaviors, resulting in the absence of consistency in treatment modalities. A case of placental site trophoblastic tumor that extended to the cervix, with primary manifestation of amenorrhea and yellow foul-smelling vaginal discharge, is presented. Total abdominal hysterectomy was performed initially, and serial measurements of human chorionic gonadotropin levels were obtained. She was admitted with metastases to brain and lung 1.5 years after surgery. Combination chemotherapy (etoposide-methotrexate-dactinomycin/cyclophosphamide-vincristine) and radiotherapy were administered. There was no significant response to chemoradiotherapy. Despite changing chemotherapy regimen, she is still alive with progressive disease.

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Citations

Aug 19, 2007·Journal of Cancer Research and Clinical Oncology·Nadereh Behtash, Mojgan Karimi Zarchi
Aug 31, 2010·Spine·Muhammad Omar ChohanPaul Turner
Jan 16, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yuh-Yu ChouTsui-Lien Mao
Feb 13, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·B PiuraR Shaco-Levy
Jun 17, 2005·World Journal of Surgical Oncology·Nadereh BehtashMalihe Hasanzadeh
Aug 1, 2009·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·L SavelliS Venturoli
Sep 30, 2016·Iranian Journal of Radiology : a Quarterly Journal Published by the Iranian Radiological Society·Maryam NiknejadiFarnaz Akhbari

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