Placental sulphate transport: a review of functional and molecular studies

Placenta
D B Shennan

Abstract

Sulphate is required by the feto-placental unit for a number of important conjugation and biosynthetic pathways. Functional studies performed several decades ago established that sulphate transport in human placental microvillus and basal membrane vesicles was mainly via a DIDS-sensitive anion-exchange mechanism. In contrast, no evidence was found for Na⁺-dependent transport. Studies performed using isolated human placental tissue confirmed anion-exchange as the main mechanism. More recently, molecular studies have established the presence of anion-exchange proteins which could play a role in transplacental sulphate movement. However, the presence of transcripts for NaS2 has been reported and has prompted the suggestion that Na⁺-sulphate cotransport may play an important role in maternal-fetal sulphate transport. This article reviews our present knowledge of placental sulphate transport, both functional and molecular, and attempts to form a model based on the available evidence.

References

May 7, 1991·Biochimica Et Biophysica Acta·D E Cole, N Rastogi
Apr 14, 1989·Biochimica Et Biophysica Acta·C Ogin, S M Grassl
Nov 1, 1988·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·J C BustamanteC A Boyd
Jan 1, 1988·The British Journal of Nutrition·D B Shennan
Nov 1, 1985·Pediatric Research·M G Brunette, S Allard
Mar 1, 1984·American Journal of Obstetrics and Gynecology·D E ColeL J Stirk
Jun 13, 1996·Biochimica Et Biophysica Acta·S M Grassl
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·J P GirardF Amalric
Jul 18, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S HailaU Saarialho-Kere
Feb 9, 2002·The Journal of Biological Chemistry·Hannes LohiJuha Kere
Mar 11, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jean-Baptiste VincourtJean-Philippe Girard
Sep 11, 2003·American Journal of Physiology. Renal Physiology·Snezana PetrovicManoocher Soleimani
Aug 1, 1963·Archives of Disease in Childhood·L J BUTTERFIELD, D O'BRIEN
Dec 14, 2004·The Journal of Biological Chemistry·Kil Hwan KimShmuel Muallem
Dec 21, 2004·Biochemical and Biophysical Research Communications·Daniel MarkovichPaul A Dawson
May 13, 2005·Pflügers Archiv : European journal of physiology·Paul A DawsonDaniel Markovich
Apr 11, 2008·Physiology·Michael R DorwartShmuel Muallem
Feb 8, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Daniel Markovich
Mar 16, 2011·The Journal of Reproduction and Development·Paul Anthony DawsonDaniel Markovich
Mar 23, 2011·Seminars in Cell & Developmental Biology·Paul A Dawson

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