Placental system A amino acid transport is reduced in pregnancies with small for gestational age (SGA) infants but not in preeclampsia with SGA infants.

Placenta
E ShibataJames M Roberts

Abstract

Preeclampsia and intrauterine growth restriction (IUGR) are both associated with abnormal remodeling of maternal spiral arteries perfusing the placental site. This would be expected to be associated with reduced fetal growth, yet only one third of infants of mothers with preeclampsia are growth restricted. Infants with IUGR have decreased concentrations of amino acids in their blood and system A amino acid transporter activity is reduced in their placentas. Since infants of preeclamptic pregnancies have increased circulating amino acids, we tested system A amino acid transport activity of placental villous fragments from pregnancies with small for gestational age (SGA) infants with and without maternal preeclampsia and from uncomplicated and preeclamptic pregnancies with normal sized infants. We confirm the reduced uptake of amino acids in SGA pregnancies without preeclampsia but report that placental amino acid uptake of SGA infants with maternal preeclampsia is not reduced and is identical to uptake by normal and preeclamptic pregnancies with normal weight infants.

References

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Citations

Apr 1, 2013·Journal of Developmental Origins of Health and Disease·F GaccioliT Jansson
Oct 27, 2011·American Journal of Physiology. Endocrinology and Metabolism·Christina E HaywardRebecca L Jones
Feb 26, 2016·Frontiers in Physiology·Francesca Gaccioli, Susanne Lager
Feb 24, 2016·Frontiers in Physiology·Christina E HaywardMark R Dilworth
Aug 30, 2012·The Journal of Physiology·Owen R VaughanAbigail L Fowden
Nov 3, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·V GourvasD A Spandidos
Jul 2, 2010·The Journal of Pathology·Joanna L JamesJudith E Cartwright
Oct 23, 2009·American Journal of Obstetrics and Gynecology·Monique A HuismanJanJaap H M Erwich
Dec 17, 2008·Placenta·J M Roberts, C A Hubel
Jan 10, 2018·Frontiers in Physiology·Christina E HaywardMark R Dilworth
Feb 22, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Lone N NørgaardThomas Bergholt
Dec 6, 2019·Journal of Applied Physiology·Owen R VaughanThomas Jansson
Oct 3, 2020·Scientific Reports·Kirsty R McIntyreMark R Dilworth
Aug 31, 2018·Frontiers in Physiology·Lewis J RenshallMark R Dilworth
Dec 4, 2020·Physiological Reviews·Daniel J HoffmanDaniel B Hardy
Nov 12, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Laura E CoatsBarbara T Alexander
Dec 31, 2020·Human Reproduction Update·Arthur ColsonAmanda N Sferruzzi-Perri
Apr 28, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Aurélie BourdonDominique Darmaun

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