PMID: 10589053Dec 11, 1999

Placental thickness at mid-pregnancy as a predictor of Hb Bart's disease

Prenatal Diagnosis
Theera TongsongSupatra Sirichotiyakul

Abstract

The measurement of placental thickness can effectively differentiate normal pregnancies from affected pregnancies requiring invasive work-up. The objective was to evaluate the efficacy of placental thickness at mid-pregnancy in predicting fetal Hb Bart's disease in pregnancies at risk. Among 17 254 pregnant women screened for severe thalassaemia between June 1994 and December 1998, 345 pregnancies at risk for having a fetus with Hb Bart's disease underwent ultrasound examinations and cordocentesis at 18-21 gestational weeks. Before cordocentesis, the placental thickness was measured and recorded. The definite fetal diagnosis was performed with high performance liquid chromatography. The efficacy of placental thickness in predicting Hb Bart's disease was evaluated by sensitivity and specificity. Various cut-off values of the placental thickness were used for calculation and the best cut-off value was determined by a receiver-operating characteristic (ROC) curve. Of 345 pregnancies at risk, 70 fetuses with Hb Bart's disease were finally diagnosed. The mean placental thickness (+/-SD) of the normal pregnancies and pregnancies with Hb Bart's fetuses were significantly different, 24.6+/-5.2 mm and 34. 5+/-6.7 mm, respectively (Stude...Continue Reading

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Citations

Feb 2, 2013·Journal of Clinical and Diagnostic Research : JCDR·T KarthikeyanK Prabhu
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Sep 11, 2020·ESC Heart Failure·Keooudone ThammavongTheera Tongsong

Related Concepts

High Pressure Liquid Chromatography Procedure
Placenta
Pregnancy Trimester, Second
Receiver Operating Characteristic
Fetal Ultrasonography
Alpha-Thalassemia
Intrauterine Cordocentesis
High-Risk Pregnancy

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