PMID: 8595127Nov 1, 1995Paper

Placental tissue from human miscarriages expresses class II HLA-DR antigens

American Journal of Reproductive Immunology : AJRI
I AthanassakisS Vassiliadis

Abstract

Class II major histocompatibility antigens occupy a central role in the development of humoral or cellular immunologic responses. Surprisingly, in the maternal-fetal interphase, where two genetically different organisms come in direct contact, these antigens are absent. Based on previous studies in mice we have demonstrated that the absence of class II antigens represents another mechanism of fetal protection from the maternal immune response and, furthermore, that the induction of these antigens in the placenta makes the tissue immunogenic and susceptible to maternal immune attack, leading thus to fetal abortion. In order to test this hypothesis in humans, we analyzed the presence of class II antigens in aborted placentae. Class II expression on aborted placentae was examined by immunoperoxidase staining on frozen sections. We also studied hematologic changes that accompany such events, measuring white and red blood cell counts, hematocrit, hemoglobin, as well as IgG serum levels by standard techniques. The detection of class II antigens on the aborted tissue indicates that these antigens are indeed major components of a pathway, which leads to a plethora of abnormal phenomena for the maternal organism such as low hematocrit l...Continue Reading

References

Apr 1, 1992·American Journal of Obstetrics and Gynecology·J A HillD J Anderson
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A Kanbour-ShakirT J Gill
Apr 13, 1990·Science·S KovatsR DeMars
Jan 15, 1985·American Journal of Obstetrics and Gynecology·P A QuinnW Hannah
Jan 1, 1995·Mediators of Inflammation·I Athanassakis

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Citations

Oct 16, 2001·Journal of Reproductive Immunology·P J van den ElsenH E Viëtor
Aug 1, 1996·American Journal of Reproductive Immunology : AJRI·I AthanassakisS Vassiliadis
Jul 9, 2004·Reproductive Biology and Endocrinology : RB&E·Shawn P MurphyRenae Holtz
Oct 31, 2009·The International Journal of Developmental Biology·Elizabeth S TaglauerMargaret G Petroff
Feb 25, 2011·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Philip J KatzmanDarryl A Oble
Oct 14, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·I AthanassakisS Vassiliadis
Feb 27, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Wen-Hui ZhouDa-Jin Li
Aug 24, 2017·Stem Cells Translational Medicine·Rebecca Lim
Nov 27, 2008·American Journal of Reproductive Immunology : AJRI·Antonis MakrigiannakisAris Antsaklis
Jun 14, 2012·International Journal of Molecular Medicine·Ruyue ShaoYingxiong Wang
Oct 9, 2007·Cell Biology International·Wei-Hua YanWei-Wu Shi
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A C MorrisJ M Boss
Jul 11, 2003·American Journal of Reproductive Immunology : AJRI·Gert DatemaPeter J van den Elsen
Mar 3, 2020·Frontiers in Immunology·Franciane Mouradian Emidio TeixeiraMaria Notomi Sato
Jul 9, 2020·International Journal of Molecular Sciences·Chiara TersigniNicoletta Di Simone

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