PMID: 6407846Jan 1, 1983Paper

Placental transfer and hormonal effects of metoclopramide

European Journal of Clinical Pharmacology
P ArvelaR Tuimala

Abstract

In order to study the transplacental transfer of metoclopramide, and its endocrine effects, measurements were made of its concentration in maternal and fetal blood, and in the amniotic fluid, together with maternal and fetal plasma concentrations of prolactin, TSH and oestradiol, during delivery by selective Caesarean section. The drug, 10 mg, was injected i.m. 12 and 2 h and just before the onset of anaesthesia. Metoclopramide was detectable in all the umbilical arterial and venous and amniotic fluid samples, in mean concentrations of 50, 63 and 75 ng/ml, respectively. The mean ratio between the umbilical venous and maternal plasma concentrations was 0.63. Accurate maternal plasma half-lives could not be established but they must have averaged 2 to 4 h. The high amniotic fluid concentrations and relatively high umbilical venous and arterial concentrations soon after administration suggest that metoclopramide equilibrates relatively rapidly between the mother and fetus. Metoclopramide raised the maternal plasma prolactin levels from 315 +/- 128 ng/ml (SD) before therapy to 357 +/- 112 ng/ml at the time birth. No statistically significant difference in cord arterial or venous plasma prolactin levels was seen between the control ...Continue Reading

References

Aug 1, 1977·Clinical Endocrinology·G L HammondR Vihko
Jan 1, 1978·Obstetrics and Gynecology·J C HauthJ M Johnston
Nov 1, 1979·British Journal of Clinical Pharmacology·C GraffnerO Rönn
May 1, 1977·The Journal of Clinical Investigation·M Hamosh, P Hamosh
Oct 1, 1978·The Journal of Clinical Investigation·P L BallardM M Grumbach
Mar 1, 1978·British Journal of Anaesthesia·J G Brock-UtneJ W Downing
Jul 1, 1975·The Journal of Clinical Investigation·M J AubertS L Kaplan
Jul 2, 1981·The New England Journal of Medicine·K Schulze-Delrieu

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Citations

Jan 1, 1983·European Journal of Clinical Pharmacology·A KauppilaO Pelkonen
Jan 1, 1985·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A KauppilaA Ruokonen
Aug 1, 1986·Neuropharmacology·B CostallF D Tattersall
Mar 16, 2000·British Journal of Clinical Pharmacology·H T SørensenJ Baron
Sep 25, 2007·Best Practice & Research. Clinical Gastroenterology·Raja Affendi Raja Ali, Laurence J Egan
Sep 10, 2014·Alimentary Pharmacology & Therapeutics·H SchulzeA Dignass
May 1, 1988·Journal of Pharmaceutical Sciences·K W RiggsD W Rurak

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