PMID: 16502764Mar 1, 2006Paper

Placental transfer of antibiotics administered to the mother: a review

International Journal of Clinical Pharmacology and Therapeutics
G M Pacifici

Abstract

The purpose of antibiotic treatment in pregnant women is to treat the mother and/or the fetus since it is known that antibiotics administered to the mother cross the placenta and reach the fetus. A comparison of the drug concentration in maternal and fetal plasma gives an indication of the exposure of the fetus to the maternally administered antibiotics. The aim of this study was to review the literature pertaining to the placental transfer of antibiotics in man and to classify the antibiotics according to the type of transfer involved. A table has been developed for use by physicians that lists the name of the antibiotic, the drug concentration in the cord and maternal plasma at delivery and the type of transfer involved. An initial medline search was performed with the key words "placental transfer of antibiotics" with the limit of "human". A second medline search was performed with the key words "placental transfer of..." followed by the class names of the antibiotic such as penicillins, cephalosporins, aminoglycosides, tetracyclines and macrolides. The bibliographic search on the placental transfer of antibiotics covered the period up to July 2005. 3 types of placental transfers were identified. A few antibiotics cross the ...Continue Reading

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