Placental transfer of bromocriptine in an ex vivo human placental perfusion model

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Qiaoling ZhengJun Zhang

Abstract

To determine the rate and extent of the maternal-fetal transplacental passage of bromocriptine (BCT) in the dually perfused human placental model. Twenty term placentas were included in an ex vivo human placental perfusion experiment with a closed-circuit model. At the start of the perfusion, BCT at the concentration of 10 or 100 ng/ml along with 100 µg/ml antipyrine which used as a positive marker were added to the maternal reservoir. Samples were collected for the measurements of BCT and markers of placental viability both from the maternal reservoir and fetal reservoir throughout the perfusion which lasted for 3 h. Determination of BCT was carried out with liquid chromatography-tandem mass spectrometry. At the end of the study, the concentration in the fetal compartment was 0.82 ± 0.32 ng/ml in the low concentration group and 5.02 ± 0.97 ng/ml in the high concentration group with a fetal transfer rate of 6.13 ± 1.94% and 5.46 ± 0.87%, respectively. These data showed that only trace amount of BCT could transport across the human placenta in vitro which suggested that fetal exposure to maternally administered BCT may be insignificant. More additional studies are required to explore the safety of BCT administrated in pregnancy.

References

May 21, 1979·European Journal of Clinical Pharmacology·M L FriisE F Hvidberg
Sep 1, 1987·Klinische Wochenschrift·P Krupp, C Monka
Nov 15, 1972·American Journal of Obstetrics and Gynecology·H SchneiderJ Dancis
Jan 1, 1983·Reproduction, Nutrition, Development·J C ChallierM Nandakumaran
Jun 2, 2004·Clinical Pharmacokinetics·Michael R SymeJeffrey A Keelan
Jun 6, 2009·The Journal of Clinical Endocrinology and Metabolism·M KarsO M Dekkers
Jan 26, 2010·Reproductive Toxicology·Line MathiesenLisbeth Ehlert Knudsen
Nov 24, 2011·Endocrinology and Metabolism Clinics of North America·Amal Shibli-Rahhal, Janet Schlechte
Nov 24, 2012·American Journal of Obstetrics and Gynecology·Paul BerveillerJean-Marc Tréluyer
Mar 26, 2014·Archives of Gynecology and Obstetrics·Caroline Hurault-DelarueChristine Damase-Michel
Mar 26, 2015·European Journal of Endocrinology·Mark E Molitch
Jun 10, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·V KarttunenK H Vähäkangas
Jul 19, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Hua HuangJun Zhang
Aug 17, 2016·Advanced Drug Delivery Reviews·Sanaalarab Al-EnazyErik Rytting

❮ Previous
Next ❯

Citations

Sep 6, 2019·Interface Focus·Rajeendra L PemathilakaNicole N Hashemi
Apr 21, 2020·Biology of Reproduction·Hanns HelmerTorsten M Reinheimer
Nov 25, 2020·International Journal of Molecular Sciences·Babak MosavatiE Du

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Infectious Diseases in Obstetrics and Gynecology
Michael D Hnat, R E Bawdon
Infectious Diseases in Obstetrics and Gynecology
Michael D HnatGeorge D Wendel
American Journal of Obstetrics and Gynecology
B D ElliottR F Johnson
European Journal of Obstetrics, Gynecology, and Reproductive Biology
Michal KovoMarek Glezerman
© 2022 Meta ULC. All rights reserved