Placental transfer of cefazolin and piperacillin in pregnancies remote from term complicated by Rh isoimmunization

American Journal of Obstetrics and Gynecology
C E BrownR Bawdon

Abstract

Although the administration of prophylactic antibodies for intrauterine transfusion is controversial, little information is available regarding placental transfer of antibiotics administered to the mother, or whether the presence of hydrops affects this placental transfer. Sixteen intravascular intrauterine transfusions were performed in 10 patients. Seven (10 procedures) patients were given 2 gm of cefazolin before the procedure and samples were obtained by fetal vascular access. Three patients (six procedures) were given 4 gm of piperacillin and samples were similarly obtained. Specimens were obtained for fetal serum, maternal serum, and amniotic fluid antibiotic concentration. The mean serum cefazolin concentration in hydropic fetuses was 18.04 +/- 3.37 micrograms/ml, and in nonhydropic fetuses the concentration was 21.02 +/- 17.8 micrograms/ml (p = 0.72). The mean fetal serum concentration of piperacillin was 22 +/- 12 micrograms/ml. The placental transfer of both drugs was similar. We conclude that the transplacental passage of these antibiotics is prompt and that the presence of hydrops does not significantly impair the passage of cefazolin.

References

Feb 1, 1989·American Journal of Obstetrics and Gynecology·I WilkinsR L Berkowitz
Jul 1, 1987·American Journal of Obstetrics and Gynecology·R L BerkowitzK E Mehalek
Dec 1, 1988·American Journal of Obstetrics and Gynecology·B W PieletS L Dooley
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Citations

Jun 6, 2000·Advanced Drug Delivery Reviews·B V Sastry
Nov 14, 2008·American Journal of Obstetrics and Gynecology·Karel AllegaertBrian J Anderson
Aug 23, 2005·Fetal Diagnosis and Therapy·Spiros MesogitisAris Antsaklis
Oct 22, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C ChatzakisA Sotiriadis
Jun 24, 2017·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Stephanie McKenney GroffAzadeh Farzin
Jul 10, 2019·Pediatrics·Karen M PuopoloUNKNOWN COMMITTEE ON INFECTIOUS DISEASES

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