PMID: 3761171Jul 1, 1986Paper

Placental transfer of diphenhydramine in chronically instrumented pregnant sheep

Journal of Pharmaceutical Sciences
S D YooD W Rurak

Abstract

To study the placental transfer and pharmacokinetics of the H1 receptor blocker, diphenhydramine [2-(diphenylmethoxy)-N,N-dimethylethylamine], 100 mg of the drug was administered to four pregnant sheep (122-129 d gestation) by intravenous injection through catheters chronically implanted in the ewe and fetus. Rapid placental transfer occurred, with peak fetal plasma concentrations occurring within 5 min after injection. The fetal-maternal ratio of the area under the plasma concentration versus time curves averaged 0.85, indicating significant fetal exposure to the drug. The average apparent terminal elimination half-life in the ewe (52 min) was not significantly different from that obtained in the fetus (46 min). The maternal total body clearance was 3.6 L X h-1 X kg-1, and the volume of distribution at steady state was 3.2 L/kg. In summary, this study demonstrates rapid and extensive placental transfer of diphenhydramine after maternal drug administration. Since placental permeability to lipid-soluble compounds does not differ greatly in different species, it is likely that a similar situation exists in humans.

References

Jul 1, 1976·Journal of Pharmaceutical Sciences·A J Sedman, J G Wagner
Feb 27, 1978·JAMA : the Journal of the American Medical Association·P L Doering, R B Stewart
Jun 1, 1975·Journal of Pharmacokinetics and Biopharmaceutics·K S AlbertJ G Wagner
Feb 1, 1982·Anesthesia and Analgesia·H PedersenB G Covino

❮ Previous
Next ❯

Citations

Nov 2, 2004·Archives of Gynecology and Obstetrics·A E Czeizel, P Vargha
Jan 1, 1991·Comparative Biochemistry and Physiology. A, Comparative Physiology·S Chiavegatto, M M Bernardi
May 1, 1988·Journal of Pharmaceutical Sciences·K W RiggsD W Rurak
Jan 1, 1987·Journal of Pharmaceutical Sciences·M KhanC T Hung
May 20, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·W W CrawfordI M Placik
May 9, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Sam C S Au-YeungDan W Rurak
Jan 28, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·John KimDan W Rurak
Feb 1, 1990·Journal of Pharmaceutical Sciences·S D YooD W Rurak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Birth Defects Research. Part B, Developmental and Reproductive Toxicology
Yalcin Tekol
Biology of the Neonate
M H MalloyW J McGanity
Journal of Perinatology : Official Journal of the California Perinatal Association
A A Miller
Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology
R G AlmeidaM M Bernardi
© 2021 Meta ULC. All rights reserved