PMID: 9652831Jul 4, 1998Paper

Placental transfer of IgG and IgG subclass antibodies anti-purified Escherichia coli LPS O16, O6 and O111

Scandinavian Journal of Immunology
A T NagaoMagda Maria Sales Carneiro-Sampaio

Abstract

We evaluated 22 paired maternal and cord sera regarding the presence of IgG and IgG subclasses against purified Escherichia coli LPS O6, O16 and O111 employing ELISA for titre and avidity analysis, isoelectric focusing associated with affinity-blotting for spectrotypic analysis, and the Western-blotting technique for recognition of the various bands in lipopolysaccharide (LPS). Levels of anti-LPS IgG antibodies in cord sera were equivalent to their respective maternal sera, showing a significant correlation (P < 0.0001). IgG1 antibody levels were higher in cord sera than in maternal sera (P < 0.005 for anti-O111, P < 0.05 for anti-O16 and P < 0.02 for anti-O6). Cord IgG2 antibody levels were not different from the maternal levels (P > 0.1). The levels of IgG3 and IgG4 were undetectable. The avidity of anti-O6 and anti-O111 IgG in 10 cord sera showed an extremely significant correlation with maternal antibody avidity (P < 0.0001). Identical patterns of recognition were found in the paired samples analysed by Western blotting. Most of the serum samples recognized the O-repetitive chains and also the region corresponding to core and lipid A. Although the antibody spectrotypes varied among individuals, paired cord and maternal seru...Continue Reading

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Citations

Oct 24, 2006·European Journal of Pediatrics·Patricia PalmeiraMagda Maria Sales Carneiro-Sampaio
Feb 18, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Patricia PalmeiraMagda M S Carneiro-Sampaio
Nov 7, 2006·Scandinavian Journal of Immunology·L B Zapata-QuintanillaS B Carbonare
Oct 19, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Eric A VasiliauskasMarla C Dubinsky
Jul 29, 2006·FEMS Immunology and Medical Microbiology·Gerlândia Neres PontesAparecida Tiemi Nagao
Nov 17, 2016·Revista da Associação Médica Brasileira·Patricia Palmeira, Magda Carneiro-Sampaio
Jun 30, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Renato Evando Moreira FilhoJosé Júlio Costa Sidrim
Apr 22, 2021·The Biochemical Journal·J Sebastian TemmeJeffrey C Gildersleeve
Nov 5, 1999·Clinical and Diagnostic Laboratory Immunology·M H ShearerR C Kennedy

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