Placental transport of threonine and its utilization in the normal and growth-restricted fetus

The American Journal of Physiology
A H AndersonFrederick C Battaglia

Abstract

Placental transport and fetoplacental utilization of threonine (Thr) were compared at 130 +/- 1 days gestational age between seven control ewes (C) and six ewes in which intrauterine growth restriction (IUGR) had been induced by exposure to high ambient temperature from 33 +/- 1 to 112 +/- 2 days of gestation. The fluxes were measured using simultaneous intravenous infusions of L-[1-13C]Thr into the mother and L-[U-14C]Thr into the fetus. The IUGR group had less fetal weight (1.27 +/- 0.14 vs. 3.10 +/- 0.10 kg, P < 0.01) and placental weight (120 +/- 17 vs. 295 +/- 14 g, P < 0.01) than the C group. The direct flux of maternal Thr into the fetal systemic circulation was less in the IUGR fetuses, both relative to fetal weight (1.40 +/- 0.19 vs. 2.19 +/- 0.18 mumol.min-1.kg fetus-1, P = 0.0107) and placental weight (1.5 +/- 0.2 vs. 2.3 +/- 0.2 mumol.min-1.100 g placenta-1, P = 0.0187). In both groups, there was excretion of CO2 produced from fetal Thr. The rate of CO2 production from fetal plasma Thr carbon by fetus plus placenta was reduced in the IUGR group (1.50 +/- 0.23 vs. 2.86 +/- 0.32 mumol.min-1.kg fetus-1, P = 0.0065). We conclude that the flux of maternal Thr into the IUGR fetus is markedly reduced because of a reduction...Continue Reading

References

Jan 1, 1990·American Journal of Obstetrics and Gynecology·I CetinF C Battaglia
May 1, 1986·The American Journal of Clinical Nutrition·X H ZhaoV R Young
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Citations

Aug 8, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Priyadarshini PanthamThomas Jansson
Apr 26, 2000·American Journal of Physiology. Endocrinology and Metabolism·P B DarlingP B Pencharz
Dec 20, 2000·American Journal of Physiology. Endocrinology and Metabolism·C L PaoliniR B Wilkening
Aug 30, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Paul J RozanceSteven H Abman
Aug 19, 2004·American Journal of Physiology. Endocrinology and Metabolism·Barbra de VrijerFrederick C Battaglia
Jan 15, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sean W LimesandWilliam W Hay
Mar 25, 2017·The Journal of Physiology·Amanda N Sferruzzi-PerriAbigail L Fowden
Sep 27, 2007·American Journal of Physiology. Endocrinology and Metabolism·Sean W LimesandWilliam W Hay

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