Placentation, maternal-fetal interface, and conceptus loss in swine

Theriogenology
Rami T KridliC Tayade

Abstract

Pregnancy is a delicate yet complex physiological process that requires fine-tuning of many factors (hormones, growth factors, cytokines, and receptors) between the mother and the conceptus to ensure the survival of the conceptus(es) to term. Any disturbance in the maternal-conceptus dialog can have detrimental effects on the affected conceptus or even the outcome of pregnancy as a whole. Being a litter-bearing species, such disruptions can lead to a loss of up to 45% of the totally healthy offspring during early (periattachment) and midgestation to late gestation in pigs. Although the exact mechanism is not entirely understood, several factors have been associated with the fetal loss including but not limited to uterine capacity, placental efficiency, genetics, nutrition, and deficits in vascularization at the maternal-fetal interface. Over the years, we investigated how immune cells are recruited to the porcine maternal-fetal interface and whether they contribute to vascularization. We also delineated how cytokines, chemokines, and cytokine destabilizing factors fine-tune inflammation and whether the cytokine shift from early to midpregnancy exists at the porcine maternal-fetal interface. Finally, we evaluated the role of mic...Continue Reading

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Citations

Apr 28, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hamid Reza NejabatiMohammad Nouri
Apr 30, 2017·Molecular Reproduction and Development·Sarah A RobertsonJohn E Schjenken
Sep 15, 2016·Reproduction, Fertility, and Development·R PasquarielloJ L Williams
Nov 17, 2017·Journal of Developmental Origins of Health and Disease·G Y SongC Qiao
Oct 18, 2018·Biology of Reproduction·Laila A IbrahimJohn J Bromfield
Jan 8, 2020·Animal : an International Journal of Animal Bioscience·B B D MuroA F C de Andrade
Feb 22, 2021·Theriogenology·Martyna M MałopolskaPawel M Bartlewski
Jul 4, 2021·Scientific Reports·Ewelina Goryszewska-SzczurekAgnieszka Waclawik

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