Plan Quality and Treatment Efficiency for Radiosurgery to Multiple Brain Metastases: Non-Coplanar RapidArc vs. Gamma Knife

Frontiers in Oncology
Haisong LiuWenyin Shi

Abstract

This study compares the dosimetry and efficiency of two modern radiosurgery [stereotactic radiosurgery (SRS)] modalities for multiple brain metastases [Gamma Knife (GK) and LINAC-based RapidArc/volumetric modulated arc therapy], with a special focus on the comparison of low-dose spread. Six patients with three or four small brain metastases were used in this study. The size of targets varied from 0.1 to 10.5 cc. SRS doses were prescribed according to the size of lesions. SRS plans were made using both Gamma Knife(®) Perfexion and a single-isocenter, multiple non-coplanar RapidArc(®). Dosimetric parameters analyzed included RTOG conformity index (CI), gradient index (GI), 12 Gy isodose volume (V 12Gy) for each target, and the dose "spread" (Dspread) for each plan. Dspread reflects SRS plan's capability of confining radiation to within the local vicinity of the lesion and to not spread out to the surrounding normal brain tissues. Each plan has a dose (Dspread), such that once dose decreases below Dspread (on total tissue dose-volume histogram), isodose volume starts increasing dramatically. Dspread is defined as that dose when volume increase first exceeds 20 cc/0.1 Gy dose decrease. RapidArc SRS has smaller CI (1.19 ± 0.14 vs. 1...Continue Reading

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Citations

Oct 6, 2018·Journal of Applied Clinical Medical Physics·Peter S PotrebkoMatthew Biagioli
Jul 23, 2019·Journal of Applied Clinical Medical Physics·Kang-Hyun AhnBulent Aydogan
Sep 12, 2019·Journal of Applied Clinical Medical Physics·Tomohiro SagawaTeruki Teshima
Jul 7, 2020·Journal of Applied Clinical Medical Physics·LiCheng KuoÅse M Ballangrud
Aug 24, 2019·Frontiers in Oncology·Samir Abdallah HannaWellington Furtado Pimenta Neves-Junior
Aug 17, 2018·Medicines·Mark O'BeirnPaul Sanghera
Feb 25, 2018·Journal of Applied Clinical Medical Physics·Åse BallangrudJames Mechalakos
Jan 5, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A Di RitoJ Thariat
Feb 18, 2021·Journal of Applied Clinical Medical Physics·Dharmin D DesaiIvan L Cordrey
Mar 17, 2021·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Jialu LaiLin Zhou
Jan 1, 2019·Clinical Genitourinary Cancer·Zabi WardakRobert Timmerman
Jun 8, 2021·Current Treatment Options in Oncology·Balamurugan A VellayappanSimon S Lo
May 8, 2021·Journal of Applied Clinical Medical Physics·Dharmin D DesaiE L Johnson

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Methods Mentioned

BETA
Gamma Knife

Software Mentioned

Varian Eclipse
Elekta GammaPlan TPS
Prism
Varian Eclpise
MIMVISTA
Elekta GammaPlan
Varian Eclipse TPS
GammaPlan
RapidArc
Varian

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