Planar microfluidic drop splitting and merging

Lab on a Chip
Sean CollignonLeslie Y Yeo

Abstract

Open droplet microfluidic platforms offer attractive alternatives to closed microchannel devices, including lower fabrication cost and complexity, significantly smaller sample and reagent volumes, reduced surface contact and adsorption, as well as drop scalability, reconfigurability, and individual addressability. For these platforms to be effective, however, they require efficient schemes for planar drop transport and manipulation. While there are many methods that have been reported for drop transport, it is far more difficult to carry out other drop operations such as dispensing, merging and splitting. In this work, we introduce a novel alternative to merge and, more crucially, split drops using laterally-offset modulated surface acoustic waves (SAWs). The energy delivery into the drop is divided into two components: a small modulation amplitude excitation to initiate weak rotational flow within the drop followed by a short burst in energy to induce it to stretch. Upon removal of the SAW energy, capillary forces at the center of the elongated drop cause the liquid in this capillary bridge region to drain towards both ends of the drop, resulting in its collapse and therefore the splitting of the drop. This however occurs only...Continue Reading

References

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Citations

Nov 26, 2015·Analytical Chemistry·Damith E W PatabadigeChristopher T Culbertson
Jan 9, 2016·Advanced Materials·Amgad R RezkLeslie Y Yeo
Mar 5, 2016·Analytical Chemistry·Ghulam DestgeerHyung Jin Sung
Jun 4, 2015·Lab on a Chip·Ivo LeibacherJürg Dual
Jul 21, 2016·Lab on a Chip·Jin Ho JungHyung Jin Sung
Jun 21, 2018·Lab on a Chip·William ConnacherJames Friend
Apr 25, 2018·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Thomas R CareyLydia L Sohn
Jun 25, 2020·Science Advances·Peiran ZhangTony Jun Huang
Jul 28, 2018·Nature Communications·Steven Peiran ZhangTony Jun Huang
May 30, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Vickramjeet SinghHeng-Kwong Tsao

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