Planarian GSK3s are involved in neural regeneration.

Development Genes and Evolution
Teresa AdellEmili Saló

Abstract

Glycogen synthase kinase-3 (GSK3) is a key element in several signaling cascades that is known to be involved in both patterning and neuronal organization. It is, therefore, a good candidate to play a role in neural regeneration in planarians. We report the characterization of three GSK3 genes in Schmidtea mediterranea. Phylogenetic analysis shows that Smed-GSK3.1 is highly conserved compared to GSK3 sequences from other species, whereas Smed-GSK3.2 and Smed-GSK3.3 are more divergent. Treatment of regenerating planarians with 1-azakenpaullone, a synthetic GSK3 inhibitor, suggests that planarian GSK3s are essential for normal differentiation and morphogenesis of the nervous system. Cephalic ganglia appear smaller and disconnected in 1-azakenpaullone-treated animals, whereas visual axons are ectopically projected, and the pharynx does not regenerate properly. This phenotype is consistent with a role for Smed-GSK3s in neuronal polarization and axonal growth.

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Citations

Jan 14, 2010·Apoptosis : an International Journal on Programmed Cell Death·Cristina González-Estévez, Emili Saló
Oct 8, 2008·Neuroscience Bulletin·Yan-Fen ZhangDa-Yong Wang
Oct 12, 2010·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Changxin MaWei Wu
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Nov 2, 2016·Regeneration·Michelle E DeochandWendy S Beane
May 2, 2019·Development Genes and Evolution·Jimena MontagneUriel Koziol
Oct 13, 2019·Developmental Biology·Samir A BelloJosé E García-Arrarás
May 1, 2018·Seminars in Cell & Developmental Biology·Nicholas S StrandRicardo M Zayas

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