Planning face, hand, and leg movements: anatomical constraints on preparatory inhibition.

Journal of Neurophysiology
Ludovica LabrunaRichard B Ivry

Abstract

Motor-evoked potentials (MEPs), elicited by transcranial magnetic stimulation (TMS) over the motor cortex, are reduced during the preparatory period in delayed response tasks. In this study we examined how MEP suppression varies as a function of the anatomical organization of the motor cortex. MEPs were recorded from a left index muscle while participants prepared a hand or leg movement in experiment 1 or prepared an eye or mouth movement in experiment 2. In this manner, we assessed if the level of MEP suppression in a hand muscle varied as a function of the anatomical distance between the agonist for the forthcoming movement and the muscle targeted by TMS. MEP suppression was attenuated when the cued effector was anatomically distant from the hand (e.g., leg or facial movement compared with finger movement). A similar effect was observed in experiment 3 in which MEPs were recorded from a muscle in the leg and the forthcoming movement involved the upper limb or face. These results demonstrate an important constraint on preparatory inhibition: it is sufficiently broad to be manifest in a muscle that is not involved in the task, but it is not global, showing a marked attenuation when the agonist muscle belongs to a different segm...Continue Reading

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Citations

Jul 25, 2019·Journal of Neurophysiology·Corey G WadsleyWinston D Byblow
Jan 22, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Gerard Derosiere, Julie Duque
Dec 29, 2020·Journal of Neurophysiology·Isaac N GomezIan Greenhouse
Apr 4, 2021·Scientific Reports·Laurie GeersMichael Andres
Jul 2, 2021·NeuroImage. Clinical·Caroline QuoilinJulie Duque

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