Plant-based corosolic acid: future anti-diabetic drug?

Biotechnology Journal
Ganapathy SivakumarJackson O Lay

Abstract

Diabetes is one of the nation's most prevalent, debilitating and costly diseases. For diabetes, frequent insulin treatment is very expensive and may increase anti-insulin antibody production, which may cause unwanted side effects. Corosolic acid may also have some efficacy in the treatment of diabetes, but without induction of anti-insulin antibodies. Recently, corosolic acid from Lagerstroemia speciosa L. leaf extracts has been reported to act via an indirect mechanism (unlike insulin) in animal experiments. The insulin-complementary anti-diabetic therapeutic value observed in these Japanese preliminary clinical trials has led to renewed interest in the biosynthesis of this compound. So far, there has been no clear evidence for a corosolic acid biosynthetic pathway in plants. This article provides possible roles of corosolic acid and hypothetical information on the biosynthetic pathway in plants.

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Citations

Mar 2, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jie YangXiao-Dong Wen
Jan 1, 2015·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Kristýna Schneiderová, Karel Šmejkal
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Aug 31, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xu-Ping QianYong-Qing Wang

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