Plant-based diets, insulin sensitivity and inflammation in elderly men with chronic kidney disease.

Journal of Nephrology
Ailema González-OrtizJuan J Carrero

Abstract

In persons with CKD, adherence to plant-based diets is associated with lower risk of CKD progression and death, but underlying mechanisms are poorly characterized. We here explore associations between adherence to plant-based diets and measures of insulin sensitivity and inflammation in men with CKD stages 3-5. Cross-sectional study including 418 men free from diabetes, aged 70-71 years and with cystatin-C estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m2 and not receiving kidney-specific dietetic advice. Information from 7-day food records was used to evaluate the adherence to a plant-based diet index (PBDi), which scores positively the intake of plant-foods and negatively animal-foods. Insulin sensitivity and glucose disposal rate were assessed with the gold-standard hyperinsulinemic euglycemic glucose clamp technique. Inflammation was evaluated by serum concentrations of C-reactive protein (CRP) and interleukin (IL)-6. Associations were explored through linear regression and restricted cubic splines. The majority of men had CKD stage 3a. Hypertension and cardiovascular disease were the most common comorbidities. The median PBDi was 38 (range 14-55). Across higher quintiles of PBDi (i.e. higher adherence), partici...Continue Reading

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Citations

Sep 3, 2020·Journal of Nephrology·Alice SabatinoCarla Maria Avesani
Oct 7, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ailema González-OrtizJuan Jesús Carrero
Jan 12, 2021·Frontiers in Medicine·Adamasco CupistiGiorgina B Piccoli
Nov 14, 2020·Current Opinion in Nephrology and Hypertension·Diana ZarantonelloGiuliano Brunori
Jan 27, 2022·Current Nutrition Reports·Baris AfsarMehmet Kanbay

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Methods Mentioned

BETA
ELISA

Software Mentioned

STATA

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