Plant begomoviruses subvert ubiquitination to suppress plant defenses against insect vectors

PLoS Pathogens
Ping LiXiao-Wei Wang

Abstract

Most plant viruses are vectored by insects and the interactions of virus-plant-vector have important ecological and evolutionary implications. Insect vectors often perform better on virus-infected plants. This indirect mutualism between plant viruses and insect vectors promotes the spread of virus and has significant agronomical effects. However, few studies have investigated how plant viruses manipulate plant defenses and promote vector performance. Begomoviruses are a prominent group of plant viruses in tropical and sub-tropical agro-ecosystems and are transmitted by whiteflies. Working with the whitefly Bemisia tabaci, begomoviruses and tobacco, we revealed that C2 protein of begomoviruses lacking DNA satellites was responsible for the suppression of plant defenses against whitefly vectors. We found that infection of plants by tomato yellow leaf curl virus (TYLCV), one of the most devastating begomoviruses worldwide, promoted the survival and reproduction of whitefly vectors. TYLCV C2 protein suppressed plant defenses by interacting with plant ubiquitin. This interaction compromised the degradation of JAZ1 protein, thus inhibiting jasmonic acid defense and the expression of MYC2-regulated terpene synthase genes. We further d...Continue Reading

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Citations

Apr 1, 2020·F1000Research·Chun-Yu Chen, Ying-Bo Mao
Sep 16, 2020·Annual Review of Entomology·Xiao-Wei Wang, Stéphane Blanc
Dec 6, 2020·Trends in Plant Science·Jian YeRongxiang Fang
Feb 9, 2021·The New Phytologist·Li-Long PanShu-Sheng Liu
Feb 13, 2021·Journal of Experimental Botany·Dibyendu Ghosh, Supriya Chakraborty
Apr 27, 2021·Frontiers in Microbiology·Karuppannan Veluthambi, Sukumaran Sunitha
Jun 3, 2021·Plants·Ullrich Dubiella, Irene Serrano

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Methods Mentioned

BETA
transgenic
two-hybrid
pull-down
PCR
ubiquitination

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