Plant Cyclophilins: Multifaceted Proteins With Versatile Roles

Frontiers in Plant Science
Harpreet SinghPrabhjeet Singh

Abstract

Cyclophilins constitute a family of ubiquitous proteins that bind cyclosporin A (CsA), an immunosuppressant drug. Several of these proteins possess peptidyl-prolyl cis-trans isomerase (PPIase) activity that catalyzes the cis-trans isomerization of the peptide bond preceding a proline residue, essential for correct folding of the proteins. Compared to prokaryotes and other eukaryotes studied until now, the cyclophilin gene families in plants exhibit considerable expansion. With few exceptions, the role of the majority of these proteins in plants is still a matter of conjecture. However, recent studies suggest that cyclophilins are highly versatile proteins with multiple functionalities, and regulate a plethora of growth and development processes in plants, ranging from hormone signaling to the stress response. The present review discusses the implications of cyclophilins in different facets of cellular processes, particularly in the context of plants, and provides a glimpse into the molecular mechanisms by which these proteins fine-tune the diverse physiological pathways.

References

Aug 1, 1992·Protein Science : a Publication of the Protein Society·L D ZydowskyC T Walsh
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·E S DavisM B Brennan
Jun 15, 1992·European Journal of Biochemistry·L A ComptonH P Bächinger
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C S GasserS M Brown
Jun 1, 1991·Trends in Biochemical Sciences·D J KenanJ D Keene
Feb 8, 1991·Cell·P S FreemontJ Trowsdale
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·E R PriceC T Walsh
Oct 1, 1990·Plant Molecular Biology·T W ConnerJ L Key
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J LiuC T Walsh
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J Liu, C T Walsh
Apr 1, 1989·Genes & Development·R J BandziulisG Dreyfuss
May 5, 1985·Journal of Molecular Biology·A TheologisR W Davis
Jan 1, 1968·Advances in Protein Chemistry·G N Ramachandran, V Sasisekharan
Nov 2, 1984·Science·R E HandschumacherD W Speicher
Nov 23, 1984·Biochimica Et Biophysica Acta·G FischerA Schellenberger
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·T BreuderJ Heitman
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·A MatouschekG Schatz
Jul 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·F Confalonieri, M Duguet
Aug 25, 1995·Journal of Molecular Biology·S AbelA Theologis
Jul 1, 1995·Trends in Biochemical Sciences·J R LambP Hieter
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R LoveringP S Freemont
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K SykesJ Sambrook
Nov 1, 1994·Plant Molecular Biology·J MarivetG Burkard
Jan 1, 1993·Advances in Protein Chemistry·F X SchmidE R Schönbrunner
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S K AndersonJ R Ortaldo
Aug 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E J Young
Mar 1, 1996·Journal of Bacteriology·S W Lazar, R Kolter

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Methods Mentioned

BETA
protein folding
transgenic
ubiquitination
nucleotide exchange
X-ray
nuclear magnetic resonance

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