Plant-Derived Lectins as Potential Cancer Therapeutics and Diagnostic Tools.

BioMed Research International
Milena Mazalovska, J Calvin Kouokam

Abstract

Cancer remains a global health challenge, with high morbidity and mortality, despite the recent advances in diagnosis and treatment. Multiple compounds assessed as novel potential anticancer drugs derive from natural sources, including microorganisms, plants, and animals. Lectins, a group of highly diverse proteins of nonimmune origin with carbohydrate-binding abilities, have been detected in virtually all kingdoms of life. These proteins can interact with free and/or cell surface oligosaccharides and might differentially bind cancer cells, since malignant transformation is tightly associated with altered cell surface glycans. Therefore, lectins could represent a valuable tool for cancer diagnosis and be developed as anticancer therapeutics. Indeed, several plant lectins exert cytotoxic effects mainly by inducing apoptotic and autophagic pathways in malignant cells. This review summarizes the current knowledge regarding the basis for the use of lectins in cancer diagnosis and therapy, providing a few examples of plant-derived carbohydrate-binding proteins with demonstrated antitumor effects.

References

Jun 1, 1986·Fertility and Sterility·L C GiudiceL Lippmann
Jan 1, 1986·Oncology·H Franz
May 3, 1987·Nature·J L BosB Vogelstein
Jan 1, 1986·Oncology·H Becker
Aug 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·J C AubM N Cote
May 1, 1981·The Biochemical Journal·H FranzA Kindt
Oct 1, 1996·Physiological Reviews·K Sandvig, B van Deurs
Dec 1, 1996·Journal of Hepatology·M Leist, A Wendel
Apr 18, 1998·Biochimica Et Biophysica Acta·R LorisL Wyns
Mar 15, 2000·The International Journal of Biochemistry & Cell Biology·W VerveckenA Büssing
Mar 28, 2001·Science·A Helenius, M Aebi
Apr 12, 2001·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J Le PenduM Clément
May 23, 2001·The Journal of Biological Chemistry·B W Yin, K O Lloyd
Jan 5, 2002·Journal of Medical Microbiology·H AnnukT Wadström
Mar 5, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maurizio BrigottiSimonetta Sperti
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Senitiroh Hakomori
Oct 12, 2002·Glycoconjugate Journal·H Rüdiger, H J Gabius
Sep 2, 2003·International Journal of Cancer. Journal International Du Cancer·Eduard ErnstMiriam Katharina Steuer-Vogt
Oct 10, 2003·Advances in Experimental Medicine and Biology·W J PeumansP Rougé
Jun 11, 2004·Annual Review of Biochemistry·Ari Helenius, Markus Aebi
Oct 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Takuya MiyagiNorio Hayashi
Aug 25, 2006·Arzneimittel-Forschung·Konrad UrechChristoph Jäggy
Dec 6, 2006·The Journal of Biological Chemistry·Nathan Sharon
Jan 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chih-Peng ChangHuan-Yao Lei
Mar 22, 2007·Annual Review of Biomedical Engineering·Sheldon WeinbaumEdward R Damiano
Mar 26, 1954·Science·W C Boyd, E Shapleigh
Oct 7, 2008·Oncogene·I Waldhauer, A Steinle
Oct 24, 2008·Journal of Agricultural and Food Chemistry·Peng Lin, Tzi Bun Ng
Dec 30, 2008·Archives of Biochemistry and Biophysics·Bo LiuJin-ku Bao

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Citations

Jan 2, 2021·International Journal of Molecular Sciences·Patrícia Ribeiro PereiraVania Margaret Flosi Paschoalin
Jan 8, 2021·International Journal of Molecular Sciences·Monika K NisiewiczAnna M Nowicka
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Kalpesh VaghasiyaRahul Kumar Verma

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Methods Mentioned

BETA
glycosylation
RIPs

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